Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase

Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is an oligomeric enzyme with crucial roles in neuronal signaling and cardiac function. Previously, we showed that activation of CaMKII triggers the exchange of subunits between holoenzymes, potentially increasing the spread of the active state (...

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Detalles Bibliográficos
Autores principales: Karandur, Deepti, Bhattacharyya, Moitrayee, Xia, Zijie, Lee, Young Kwang, Muratcioglu, Serena, McAffee, Darren, McSpadden, Ethan D, Qiu, Baiyu, Groves, Jay T, Williams, Evan R, Kuriyan, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538161/
https://www.ncbi.nlm.nih.gov/pubmed/32902386
http://dx.doi.org/10.7554/eLife.57784

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