Identification of novel mutations in SARS-COV-2 isolates from Turkey

SARS-CoV-2 was first detected in the city of Wuhan, Hubei Province, China. In this study, we identified 11 unique mutations in viral SARS-COV-2 isolates from Turkey. Nine of them cause structural alterations in the S protein, nsp2, nsp3, nsp4 and nsp12 regions. The mutations identified here might ha...

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Autores principales: Rehman, Shazia, Mahmood, Tariq, Aziz, Ejaz, Batool, Riffat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538173/
https://www.ncbi.nlm.nih.gov/pubmed/33025199
http://dx.doi.org/10.1007/s00705-020-04830-0
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author Rehman, Shazia
Mahmood, Tariq
Aziz, Ejaz
Batool, Riffat
author_facet Rehman, Shazia
Mahmood, Tariq
Aziz, Ejaz
Batool, Riffat
author_sort Rehman, Shazia
collection PubMed
description SARS-CoV-2 was first detected in the city of Wuhan, Hubei Province, China. In this study, we identified 11 unique mutations in viral SARS-COV-2 isolates from Turkey. Nine of them cause structural alterations in the S protein, nsp2, nsp3, nsp4 and nsp12 regions. The mutations identified here might have significant functional implications that need to be addressed in future studies in the context of vaccine engineering and therapeutic interventions. Moreover, transmission and phylogenetic analysis revealed multiple independent sources of introductions of SARS-CoV-2 into Turkey and a close relationship to the isolates from Saudi Arabia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00705-020-04830-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-75381732020-10-07 Identification of novel mutations in SARS-COV-2 isolates from Turkey Rehman, Shazia Mahmood, Tariq Aziz, Ejaz Batool, Riffat Arch Virol Brief Report SARS-CoV-2 was first detected in the city of Wuhan, Hubei Province, China. In this study, we identified 11 unique mutations in viral SARS-COV-2 isolates from Turkey. Nine of them cause structural alterations in the S protein, nsp2, nsp3, nsp4 and nsp12 regions. The mutations identified here might have significant functional implications that need to be addressed in future studies in the context of vaccine engineering and therapeutic interventions. Moreover, transmission and phylogenetic analysis revealed multiple independent sources of introductions of SARS-CoV-2 into Turkey and a close relationship to the isolates from Saudi Arabia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00705-020-04830-0) contains supplementary material, which is available to authorized users. Springer Vienna 2020-10-06 2020 /pmc/articles/PMC7538173/ /pubmed/33025199 http://dx.doi.org/10.1007/s00705-020-04830-0 Text en © Springer-Verlag GmbH Austria, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Report
Rehman, Shazia
Mahmood, Tariq
Aziz, Ejaz
Batool, Riffat
Identification of novel mutations in SARS-COV-2 isolates from Turkey
title Identification of novel mutations in SARS-COV-2 isolates from Turkey
title_full Identification of novel mutations in SARS-COV-2 isolates from Turkey
title_fullStr Identification of novel mutations in SARS-COV-2 isolates from Turkey
title_full_unstemmed Identification of novel mutations in SARS-COV-2 isolates from Turkey
title_short Identification of novel mutations in SARS-COV-2 isolates from Turkey
title_sort identification of novel mutations in sars-cov-2 isolates from turkey
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538173/
https://www.ncbi.nlm.nih.gov/pubmed/33025199
http://dx.doi.org/10.1007/s00705-020-04830-0
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