Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation and ER stress in CHO cells

One major challenge observed for the expression of therapeutic bispecific antibodies (BisAbs) is high product aggregates. Aggregates increase the risk of immune responses in patients and therefore must be removed at the expense of purification yields. BisAbs contain engineered disulfide bonds, which...

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Detalles Bibliográficos
Autores principales: Sinharoy, Pritam, Aziz, Aaron H., Majewska, Natalia I., Ahuja, Sanjeev, Handlogten, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538420/
https://www.ncbi.nlm.nih.gov/pubmed/33024175
http://dx.doi.org/10.1038/s41598-020-73573-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538420/
https://www.ncbi.nlm.nih.gov/pubmed/33024175
http://dx.doi.org/10.1038/s41598-020-73573-4

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