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HIF-2α is indispensable for regulatory T cell function

Hypoxia-inducible factor 1α (HIF-1α) and HIF-2α are master transcription factors that regulate cellular responses to hypoxia, but the exact function in regulatory T (Treg) cells is controversial. Here, we show that Treg cell development is normal in mice with Foxp3-specific knockout (KO) of HIF-1α o...

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Detalles Bibliográficos
Autores principales:	Hsu, Tzu-Sheng, Lin, Yen-Lin, Wang, Yu-An, Mo, Shu-Ting, Chi, Po-Yu, Lai, Alan Chuan-Ying, Pan, Hsuan-Yin, Chang, Ya-Jen, Lai, Ming-Zong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538433/ https://www.ncbi.nlm.nih.gov/pubmed/33024109 http://dx.doi.org/10.1038/s41467-020-18731-y

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