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Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death
Amyloid beta (Aβ) accumulates within neurons in the brains of early stage Alzheimer’s disease (AD) patients. However, the mechanism underlying its toxicity remains unclear. Here, a triple omics approach was used to integrate transcriptomic, proteomic, and metabolomic data collected from a nerve cell...
Autores principales: | Huang, Ling, McClatchy, Daniel B., Maher, Pamela, Liang, Zhibin, Diedrich, Jolene K., Soriano-Castell, David, Goldberg, Joshua, Shokhirev, Maxim, Yates, John R., Schubert, David, Currais, Antonio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538552/ https://www.ncbi.nlm.nih.gov/pubmed/33024077 http://dx.doi.org/10.1038/s41419-020-03020-9 |
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