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Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study
Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538555/ https://www.ncbi.nlm.nih.gov/pubmed/33024121 http://dx.doi.org/10.1038/s41467-020-18849-z |
| _version_ | 1783590888261287936 |
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| author | Burn, Edward You, Seng Chan Sena, Anthony G. Kostka, Kristin Abedtash, Hamed Abrahão, Maria Tereza F. Alberga, Amanda Alghoul, Heba Alser, Osaid Alshammari, Thamir M. Aragon, Maria Areia, Carlos Banda, Juan M. Cho, Jaehyeong Culhane, Aedin C. Davydov, Alexander DeFalco, Frank J. Duarte-Salles, Talita DuVall, Scott Falconer, Thomas Fernandez-Bertolin, Sergio Gao, Weihua Golozar, Asieh Hardin, Jill Hripcsak, George Huser, Vojtech Jeon, Hokyun Jing, Yonghua Jung, Chi Young Kaas-Hansen, Benjamin Skov Kaduk, Denys Kent, Seamus Kim, Yeesuk Kolovos, Spyros Lane, Jennifer C. E. Lee, Hyejin Lynch, Kristine E. Makadia, Rupa Matheny, Michael E. Mehta, Paras P. Morales, Daniel R. Natarajan, Karthik Nyberg, Fredrik Ostropolets, Anna Park, Rae Woong Park, Jimyung Posada, Jose D. Prats-Uribe, Albert Rao, Gowtham Reich, Christian Rho, Yeunsook Rijnbeek, Peter Schilling, Lisa M. Schuemie, Martijn Shah, Nigam H. Shoaibi, Azza Song, Seokyoung Spotnitz, Matthew Suchard, Marc A. Swerdel, Joel N. Vizcaya, David Volpe, Salvatore Wen, Haini Williams, Andrew E. Yimer, Belay B. Zhang, Lin Zhuk, Oleg Prieto-Alhambra, Daniel Ryan, Patrick |
| author_facet | Burn, Edward You, Seng Chan Sena, Anthony G. Kostka, Kristin Abedtash, Hamed Abrahão, Maria Tereza F. Alberga, Amanda Alghoul, Heba Alser, Osaid Alshammari, Thamir M. Aragon, Maria Areia, Carlos Banda, Juan M. Cho, Jaehyeong Culhane, Aedin C. Davydov, Alexander DeFalco, Frank J. Duarte-Salles, Talita DuVall, Scott Falconer, Thomas Fernandez-Bertolin, Sergio Gao, Weihua Golozar, Asieh Hardin, Jill Hripcsak, George Huser, Vojtech Jeon, Hokyun Jing, Yonghua Jung, Chi Young Kaas-Hansen, Benjamin Skov Kaduk, Denys Kent, Seamus Kim, Yeesuk Kolovos, Spyros Lane, Jennifer C. E. Lee, Hyejin Lynch, Kristine E. Makadia, Rupa Matheny, Michael E. Mehta, Paras P. Morales, Daniel R. Natarajan, Karthik Nyberg, Fredrik Ostropolets, Anna Park, Rae Woong Park, Jimyung Posada, Jose D. Prats-Uribe, Albert Rao, Gowtham Reich, Christian Rho, Yeunsook Rijnbeek, Peter Schilling, Lisa M. Schuemie, Martijn Shah, Nigam H. Shoaibi, Azza Song, Seokyoung Spotnitz, Matthew Suchard, Marc A. Swerdel, Joel N. Vizcaya, David Volpe, Salvatore Wen, Haini Williams, Andrew E. Yimer, Belay B. Zhang, Lin Zhuk, Oleg Prieto-Alhambra, Daniel Ryan, Patrick |
| author_sort | Burn, Edward |
| collection | PubMed |
| description | Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19. |
| format | Online Article Text |
| id | pubmed-7538555 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-75385552020-10-19 Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study Burn, Edward You, Seng Chan Sena, Anthony G. Kostka, Kristin Abedtash, Hamed Abrahão, Maria Tereza F. Alberga, Amanda Alghoul, Heba Alser, Osaid Alshammari, Thamir M. Aragon, Maria Areia, Carlos Banda, Juan M. Cho, Jaehyeong Culhane, Aedin C. Davydov, Alexander DeFalco, Frank J. Duarte-Salles, Talita DuVall, Scott Falconer, Thomas Fernandez-Bertolin, Sergio Gao, Weihua Golozar, Asieh Hardin, Jill Hripcsak, George Huser, Vojtech Jeon, Hokyun Jing, Yonghua Jung, Chi Young Kaas-Hansen, Benjamin Skov Kaduk, Denys Kent, Seamus Kim, Yeesuk Kolovos, Spyros Lane, Jennifer C. E. Lee, Hyejin Lynch, Kristine E. Makadia, Rupa Matheny, Michael E. Mehta, Paras P. Morales, Daniel R. Natarajan, Karthik Nyberg, Fredrik Ostropolets, Anna Park, Rae Woong Park, Jimyung Posada, Jose D. Prats-Uribe, Albert Rao, Gowtham Reich, Christian Rho, Yeunsook Rijnbeek, Peter Schilling, Lisa M. Schuemie, Martijn Shah, Nigam H. Shoaibi, Azza Song, Seokyoung Spotnitz, Matthew Suchard, Marc A. Swerdel, Joel N. Vizcaya, David Volpe, Salvatore Wen, Haini Williams, Andrew E. Yimer, Belay B. Zhang, Lin Zhuk, Oleg Prieto-Alhambra, Daniel Ryan, Patrick Nat Commun Article Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19. Nature Publishing Group UK 2020-10-06 /pmc/articles/PMC7538555/ /pubmed/33024121 http://dx.doi.org/10.1038/s41467-020-18849-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Burn, Edward You, Seng Chan Sena, Anthony G. Kostka, Kristin Abedtash, Hamed Abrahão, Maria Tereza F. Alberga, Amanda Alghoul, Heba Alser, Osaid Alshammari, Thamir M. Aragon, Maria Areia, Carlos Banda, Juan M. Cho, Jaehyeong Culhane, Aedin C. Davydov, Alexander DeFalco, Frank J. Duarte-Salles, Talita DuVall, Scott Falconer, Thomas Fernandez-Bertolin, Sergio Gao, Weihua Golozar, Asieh Hardin, Jill Hripcsak, George Huser, Vojtech Jeon, Hokyun Jing, Yonghua Jung, Chi Young Kaas-Hansen, Benjamin Skov Kaduk, Denys Kent, Seamus Kim, Yeesuk Kolovos, Spyros Lane, Jennifer C. E. Lee, Hyejin Lynch, Kristine E. Makadia, Rupa Matheny, Michael E. Mehta, Paras P. Morales, Daniel R. Natarajan, Karthik Nyberg, Fredrik Ostropolets, Anna Park, Rae Woong Park, Jimyung Posada, Jose D. Prats-Uribe, Albert Rao, Gowtham Reich, Christian Rho, Yeunsook Rijnbeek, Peter Schilling, Lisa M. Schuemie, Martijn Shah, Nigam H. Shoaibi, Azza Song, Seokyoung Spotnitz, Matthew Suchard, Marc A. Swerdel, Joel N. Vizcaya, David Volpe, Salvatore Wen, Haini Williams, Andrew E. Yimer, Belay B. Zhang, Lin Zhuk, Oleg Prieto-Alhambra, Daniel Ryan, Patrick Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study |
| title | Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study |
| title_full | Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study |
| title_fullStr | Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study |
| title_full_unstemmed | Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study |
| title_short | Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study |
| title_sort | deep phenotyping of 34,128 adult patients hospitalised with covid-19 in an international network study |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538555/ https://www.ncbi.nlm.nih.gov/pubmed/33024121 http://dx.doi.org/10.1038/s41467-020-18849-z |
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