p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability

p50, the mature product of NFKB1, is constitutively produced from its precursor, p105. Here, we identify BARD1 as a p50-interacting factor. p50 directly associates with the BARD1 BRCT domains via a C-terminal phospho-serine motif. This interaction is induced by ATR and results in mono-ubiquitination...

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Detalles Bibliográficos
Autores principales: Wu, Longtao, Crawley, Clayton D., Garofalo, Andrea, Nichols, Jackie W., Campbell, Paige-Ashley, Khramtsova, Galina F., Olopade, Olufunmilayo I., Weichselbaum, Ralph R., Yamini, Bakhtiar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538584/
https://www.ncbi.nlm.nih.gov/pubmed/33024116
http://dx.doi.org/10.1038/s41467-020-18838-2

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