Cargando…
A Systematic Framework for Olfactory Bulb Signal Transformations
We describe an integrated theory of olfactory systems operation that incorporates experimental findings across scales, stages, and methods of analysis into a common framework. In particular, we consider the multiple stages of olfactory signal processing as a collective system, in which each stage sa...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538604/ https://www.ncbi.nlm.nih.gov/pubmed/33071767 http://dx.doi.org/10.3389/fncom.2020.579143 |
_version_ | 1783590899513556992 |
---|---|
author | Cleland, Thomas A. Borthakur, Ayon |
author_facet | Cleland, Thomas A. Borthakur, Ayon |
author_sort | Cleland, Thomas A. |
collection | PubMed |
description | We describe an integrated theory of olfactory systems operation that incorporates experimental findings across scales, stages, and methods of analysis into a common framework. In particular, we consider the multiple stages of olfactory signal processing as a collective system, in which each stage samples selectively from its antecedents. We propose that, following the signal conditioning operations of the nasal epithelium and glomerular-layer circuitry, the plastic external plexiform layer of the olfactory bulb effects a process of category learning—the basis for extracting meaningful, quasi-discrete odor representations from the metric space of undifferentiated olfactory quality. Moreover, this early categorization process also resolves the foundational problem of how odors of interest can be recognized in the presence of strong competitive interference from simultaneously encountered background odorants. This problem is fundamentally constraining on early-stage olfactory encoding strategies and must be resolved if these strategies and their underlying mechanisms are to be understood. Multiscale general theories of olfactory systems operation are essential in order to leverage the analytical advantages of engineered approaches together with our expanding capacity to interrogate biological systems. |
format | Online Article Text |
id | pubmed-7538604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75386042020-10-17 A Systematic Framework for Olfactory Bulb Signal Transformations Cleland, Thomas A. Borthakur, Ayon Front Comput Neurosci Neuroscience We describe an integrated theory of olfactory systems operation that incorporates experimental findings across scales, stages, and methods of analysis into a common framework. In particular, we consider the multiple stages of olfactory signal processing as a collective system, in which each stage samples selectively from its antecedents. We propose that, following the signal conditioning operations of the nasal epithelium and glomerular-layer circuitry, the plastic external plexiform layer of the olfactory bulb effects a process of category learning—the basis for extracting meaningful, quasi-discrete odor representations from the metric space of undifferentiated olfactory quality. Moreover, this early categorization process also resolves the foundational problem of how odors of interest can be recognized in the presence of strong competitive interference from simultaneously encountered background odorants. This problem is fundamentally constraining on early-stage olfactory encoding strategies and must be resolved if these strategies and their underlying mechanisms are to be understood. Multiscale general theories of olfactory systems operation are essential in order to leverage the analytical advantages of engineered approaches together with our expanding capacity to interrogate biological systems. Frontiers Media S.A. 2020-09-23 /pmc/articles/PMC7538604/ /pubmed/33071767 http://dx.doi.org/10.3389/fncom.2020.579143 Text en Copyright © 2020 Cleland and Borthakur. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Cleland, Thomas A. Borthakur, Ayon A Systematic Framework for Olfactory Bulb Signal Transformations |
title | A Systematic Framework for Olfactory Bulb Signal Transformations |
title_full | A Systematic Framework for Olfactory Bulb Signal Transformations |
title_fullStr | A Systematic Framework for Olfactory Bulb Signal Transformations |
title_full_unstemmed | A Systematic Framework for Olfactory Bulb Signal Transformations |
title_short | A Systematic Framework for Olfactory Bulb Signal Transformations |
title_sort | systematic framework for olfactory bulb signal transformations |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538604/ https://www.ncbi.nlm.nih.gov/pubmed/33071767 http://dx.doi.org/10.3389/fncom.2020.579143 |
work_keys_str_mv | AT clelandthomasa asystematicframeworkforolfactorybulbsignaltransformations AT borthakurayon asystematicframeworkforolfactorybulbsignaltransformations AT clelandthomasa systematicframeworkforolfactorybulbsignaltransformations AT borthakurayon systematicframeworkforolfactorybulbsignaltransformations |