A Neonatal Murine Escherichia coli Sepsis Model Demonstrates That Adjunctive Pentoxifylline Enhances the Ratio of Anti- vs. Pro-inflammatory Cytokines in Blood and Organ Tissues

Introduction: Neonatal sepsis triggers an inflammatory response that contributes to mortality and multiple organ injury. Pentoxifylline (PTX), a phosphodiesterase inhibitor which suppresses pro-inflammatory cytokines, is a candidate adjunctive therapy for newborn sepsis. We hypothesized that adminis...

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Detalles Bibliográficos
Autores principales: Speer, Esther M., Diago-Navarro, Elizabet, Ozog, Lukasz S., Raheel, Mahnoor, Levy, Ofer, Fries, Bettina C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538609/
https://www.ncbi.nlm.nih.gov/pubmed/33072121
http://dx.doi.org/10.3389/fimmu.2020.577878

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