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Carbohydrates, Glycemic Index, and Glycemic Load in Relation to Bladder Cancer Risk
Objective: Epidemiologic studies investigating the association between dietary carbohydrates as well as glycemic index and glycemic load (markers of carbohydrate quality) and bladder cancer risk have yielded inconsistent results. The aim of the present meta-analysis is to summarize the evidence on t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538710/ https://www.ncbi.nlm.nih.gov/pubmed/33072566 http://dx.doi.org/10.3389/fonc.2020.530382 |
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author | Zhu, Hejia Mo, Qiwang Shen, Haixiang Wang, Song Liu, Ben Xu, Xin |
author_facet | Zhu, Hejia Mo, Qiwang Shen, Haixiang Wang, Song Liu, Ben Xu, Xin |
author_sort | Zhu, Hejia |
collection | PubMed |
description | Objective: Epidemiologic studies investigating the association between dietary carbohydrates as well as glycemic index and glycemic load (markers of carbohydrate quality) and bladder cancer risk have yielded inconsistent results. The aim of the present meta-analysis is to summarize the evidence on this association. Materials and Methods: A comprehensive literature search of articles published by December 2019 was performed in PubMed, Scopus, and Web of Science databases. A random-effects model was used to calculate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). Results: Twelve observational studies were included in the final analysis. There was no evidence of an association between consumption of carbohydrates and bladder cancer risk (pooled OR, 1.04; 95% CI, 0.92–1.17). No statistically significant association between glycemic load and bladder cancer was likewise found (pooled OR, 1.10; 95% CI, 0.85–1.42). However, there was a significant positive association between glycemic index and bladder cancer risk (pooled OR, 1.25; 95% CI, 1.11–1.41). In the dose–response analysis, the pooled OR (95% CI) per 10 units of glycemic index per day was 1.02 (95% CI, 1.01–1.04). Conclusion: In this meta-analysis, glycemic index showed a positive linear association with bladder cancer risk. |
format | Online Article Text |
id | pubmed-7538710 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75387102020-10-15 Carbohydrates, Glycemic Index, and Glycemic Load in Relation to Bladder Cancer Risk Zhu, Hejia Mo, Qiwang Shen, Haixiang Wang, Song Liu, Ben Xu, Xin Front Oncol Oncology Objective: Epidemiologic studies investigating the association between dietary carbohydrates as well as glycemic index and glycemic load (markers of carbohydrate quality) and bladder cancer risk have yielded inconsistent results. The aim of the present meta-analysis is to summarize the evidence on this association. Materials and Methods: A comprehensive literature search of articles published by December 2019 was performed in PubMed, Scopus, and Web of Science databases. A random-effects model was used to calculate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). Results: Twelve observational studies were included in the final analysis. There was no evidence of an association between consumption of carbohydrates and bladder cancer risk (pooled OR, 1.04; 95% CI, 0.92–1.17). No statistically significant association between glycemic load and bladder cancer was likewise found (pooled OR, 1.10; 95% CI, 0.85–1.42). However, there was a significant positive association between glycemic index and bladder cancer risk (pooled OR, 1.25; 95% CI, 1.11–1.41). In the dose–response analysis, the pooled OR (95% CI) per 10 units of glycemic index per day was 1.02 (95% CI, 1.01–1.04). Conclusion: In this meta-analysis, glycemic index showed a positive linear association with bladder cancer risk. Frontiers Media S.A. 2020-09-23 /pmc/articles/PMC7538710/ /pubmed/33072566 http://dx.doi.org/10.3389/fonc.2020.530382 Text en Copyright © 2020 Zhu, Mo, Shen, Wang, Liu and Xu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Zhu, Hejia Mo, Qiwang Shen, Haixiang Wang, Song Liu, Ben Xu, Xin Carbohydrates, Glycemic Index, and Glycemic Load in Relation to Bladder Cancer Risk |
title | Carbohydrates, Glycemic Index, and Glycemic Load in Relation to Bladder Cancer Risk |
title_full | Carbohydrates, Glycemic Index, and Glycemic Load in Relation to Bladder Cancer Risk |
title_fullStr | Carbohydrates, Glycemic Index, and Glycemic Load in Relation to Bladder Cancer Risk |
title_full_unstemmed | Carbohydrates, Glycemic Index, and Glycemic Load in Relation to Bladder Cancer Risk |
title_short | Carbohydrates, Glycemic Index, and Glycemic Load in Relation to Bladder Cancer Risk |
title_sort | carbohydrates, glycemic index, and glycemic load in relation to bladder cancer risk |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538710/ https://www.ncbi.nlm.nih.gov/pubmed/33072566 http://dx.doi.org/10.3389/fonc.2020.530382 |
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