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Risk factors for intracerebral haemorrhage – Results from a prospective population-based study

INTRODUCTION: While the relationship between hypertension and incident intracerebral haemorrhage is well established, other risk factors are less clear. This study examined risk factors for primary intracerebral haemorrhage, separately for lobar and non-lobar intracerebral haemorrhage. PATIENTS AND...

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Autores principales: Svensson, Edith H, Abul-Kasim, Kasim, Engström, Gunnar, Söderholm, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538759/
https://www.ncbi.nlm.nih.gov/pubmed/33072882
http://dx.doi.org/10.1177/2396987320932069
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author Svensson, Edith H
Abul-Kasim, Kasim
Engström, Gunnar
Söderholm, Martin
author_facet Svensson, Edith H
Abul-Kasim, Kasim
Engström, Gunnar
Söderholm, Martin
author_sort Svensson, Edith H
collection PubMed
description INTRODUCTION: While the relationship between hypertension and incident intracerebral haemorrhage is well established, other risk factors are less clear. This study examined risk factors for primary intracerebral haemorrhage, separately for lobar and non-lobar intracerebral haemorrhage. PATIENTS AND METHODS: Incidence of intracerebral haemorrhage was studied among 28,416 individuals from the population-based Malmö Diet and Cancer cohort. Intracerebral haemorrhage cases were ascertained using the Swedish Hospital Discharge Register and the Stroke Register of Malmö, validated by review of hospital records and images, and classified by location by a neuroradiologist. Multivariable Cox regression was used. RESULTS: Three hundred and thirty-three intracerebral haemorrhages occurred, mean follow-up time was 18.4 years. Systolic blood pressure (hazard ratio per 10 mmHg 1.19 [95% confidence interval 1.13–1.26], diastolic blood pressure (hazard ratio 1.42 [1.27–1.59]), oral anticoagulants (hazard ratio 4.26 [2.17–8.38]), smoking (hazard ratio 1.45 [1.14–1.87]), living alone (hazard ratio 1.32 [1.04–1.69]) and low apolipoprotein B (hazard ratio per 10 mg/dL: 0.94 [0.90–0.99]) were significantly associated with incident intracerebral haemorrhage after multivariable adjustment. Systolic blood pressure, smoking and oral anticoagulants were associated with lobar intracerebral haemorrhage. Systolic blood pressure, diastolic blood pressure, living alone and diabetes were associated with non-lobar intracerebral haemorrhage. Diabetes and diastolic blood pressure showed significantly different relationships with lobar and non-lobar intracerebral haemorrhage. Alcohol, apolipoprotein A1, body mass index, waist circumference, physical activity and education were not independently associated with intracerebral haemorrhage. Discussion and conclusions: Blood pressure, smoking, low apolipoprotein B, oral anticoagulants and living alone were associated with intracerebral haemorrhage. Diabetes was associated with non-lobar intracerebral haemorrhage only. Further research is required on differences between lobar and non-lobar intracerebral haemorrhage.
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spelling pubmed-75387592020-10-15 Risk factors for intracerebral haemorrhage – Results from a prospective population-based study Svensson, Edith H Abul-Kasim, Kasim Engström, Gunnar Söderholm, Martin Eur Stroke J Original Research Articles INTRODUCTION: While the relationship between hypertension and incident intracerebral haemorrhage is well established, other risk factors are less clear. This study examined risk factors for primary intracerebral haemorrhage, separately for lobar and non-lobar intracerebral haemorrhage. PATIENTS AND METHODS: Incidence of intracerebral haemorrhage was studied among 28,416 individuals from the population-based Malmö Diet and Cancer cohort. Intracerebral haemorrhage cases were ascertained using the Swedish Hospital Discharge Register and the Stroke Register of Malmö, validated by review of hospital records and images, and classified by location by a neuroradiologist. Multivariable Cox regression was used. RESULTS: Three hundred and thirty-three intracerebral haemorrhages occurred, mean follow-up time was 18.4 years. Systolic blood pressure (hazard ratio per 10 mmHg 1.19 [95% confidence interval 1.13–1.26], diastolic blood pressure (hazard ratio 1.42 [1.27–1.59]), oral anticoagulants (hazard ratio 4.26 [2.17–8.38]), smoking (hazard ratio 1.45 [1.14–1.87]), living alone (hazard ratio 1.32 [1.04–1.69]) and low apolipoprotein B (hazard ratio per 10 mg/dL: 0.94 [0.90–0.99]) were significantly associated with incident intracerebral haemorrhage after multivariable adjustment. Systolic blood pressure, smoking and oral anticoagulants were associated with lobar intracerebral haemorrhage. Systolic blood pressure, diastolic blood pressure, living alone and diabetes were associated with non-lobar intracerebral haemorrhage. Diabetes and diastolic blood pressure showed significantly different relationships with lobar and non-lobar intracerebral haemorrhage. Alcohol, apolipoprotein A1, body mass index, waist circumference, physical activity and education were not independently associated with intracerebral haemorrhage. Discussion and conclusions: Blood pressure, smoking, low apolipoprotein B, oral anticoagulants and living alone were associated with intracerebral haemorrhage. Diabetes was associated with non-lobar intracerebral haemorrhage only. Further research is required on differences between lobar and non-lobar intracerebral haemorrhage. SAGE Publications 2020-06-12 2020-09 /pmc/articles/PMC7538759/ /pubmed/33072882 http://dx.doi.org/10.1177/2396987320932069 Text en © European Stroke Organisation 2020 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Articles
Svensson, Edith H
Abul-Kasim, Kasim
Engström, Gunnar
Söderholm, Martin
Risk factors for intracerebral haemorrhage – Results from a prospective population-based study
title Risk factors for intracerebral haemorrhage – Results from a prospective population-based study
title_full Risk factors for intracerebral haemorrhage – Results from a prospective population-based study
title_fullStr Risk factors for intracerebral haemorrhage – Results from a prospective population-based study
title_full_unstemmed Risk factors for intracerebral haemorrhage – Results from a prospective population-based study
title_short Risk factors for intracerebral haemorrhage – Results from a prospective population-based study
title_sort risk factors for intracerebral haemorrhage – results from a prospective population-based study
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538759/
https://www.ncbi.nlm.nih.gov/pubmed/33072882
http://dx.doi.org/10.1177/2396987320932069
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