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The impact of morbid obesity on survival of endometrial cancer
OBJECTIVE: Morbid obesity is identified as patients with a body mass index more than 40 kg/m(2). Obesity is known as a risk factor for endometrial cancer due to the increase of the deposited estrogen. This study was conducted to evaluate the effect of morbid obesity on the survival of endometrial ca...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538820/ https://www.ncbi.nlm.nih.gov/pubmed/33072426 http://dx.doi.org/10.4274/tjod.galenos.2020.83773 |
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author | Güzel, Ahmet Barış Khatib, Ghanim Küçükgöz Güleç, Ümran Gümürdülü, Derya Vardar, Mehmet Ali |
author_facet | Güzel, Ahmet Barış Khatib, Ghanim Küçükgöz Güleç, Ümran Gümürdülü, Derya Vardar, Mehmet Ali |
author_sort | Güzel, Ahmet Barış |
collection | PubMed |
description | OBJECTIVE: Morbid obesity is identified as patients with a body mass index more than 40 kg/m(2). Obesity is known as a risk factor for endometrial cancer due to the increase of the deposited estrogen. This study was conducted to evaluate the effect of morbid obesity on the survival of endometrial cancer. MATERIALS AND METHODS: The archival records and pathologic reports of patients with endometrial cancer who underwent surgery and were followed up in Çukurova University Gynecologic Oncology Center between January 1996 and December 2018 were reviewed, retrospectively. Data regarding body mass index and survival was reported in 520 patients. These patients were stratified into two groups according to their body mass index, <40 and ≥40 kg/m(2). The groups’ clinic, pathologic features, and survival rates were compared. RESULTS: There were 146 patients in the morbidly obese group and 374 patients in the obese group. The mean age of the groups was 58.5 and 56.2 years, respectively. The mean follow-up time was 51.6 months. Comorbidities were significantly higher in the morbidly obese group. The five-year disease-free and overall survival rates were 78.3% and 85.3% in the morbidly obese group, and 81.6% and 90.1% in the obese group, respectively. Although the groups’ clinical and pathologic features were homogeneously distributed, disease-free and overall survival rates were significantly different (p=0.053 and p=0.054, respectively). CONCLUSION: Morbidly obese patients with endometrial cancer were associated with 2.7-fold increased risk of death and 1.7-fold increased risk of recurrence compared with those who had body mass index <40 kg/m(2). It is important to deal with the frequent comorbidities in this special group, which could be simply altered by lifestyle changes. Morbidly obese patients with endometrial cancer should be encouraged in lifestyle changes and consulted by dieticians and endocrinologists. |
format | Online Article Text |
id | pubmed-7538820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-75388202020-10-15 The impact of morbid obesity on survival of endometrial cancer Güzel, Ahmet Barış Khatib, Ghanim Küçükgöz Güleç, Ümran Gümürdülü, Derya Vardar, Mehmet Ali Turk J Obstet Gynecol Clinical Investigation OBJECTIVE: Morbid obesity is identified as patients with a body mass index more than 40 kg/m(2). Obesity is known as a risk factor for endometrial cancer due to the increase of the deposited estrogen. This study was conducted to evaluate the effect of morbid obesity on the survival of endometrial cancer. MATERIALS AND METHODS: The archival records and pathologic reports of patients with endometrial cancer who underwent surgery and were followed up in Çukurova University Gynecologic Oncology Center between January 1996 and December 2018 were reviewed, retrospectively. Data regarding body mass index and survival was reported in 520 patients. These patients were stratified into two groups according to their body mass index, <40 and ≥40 kg/m(2). The groups’ clinic, pathologic features, and survival rates were compared. RESULTS: There were 146 patients in the morbidly obese group and 374 patients in the obese group. The mean age of the groups was 58.5 and 56.2 years, respectively. The mean follow-up time was 51.6 months. Comorbidities were significantly higher in the morbidly obese group. The five-year disease-free and overall survival rates were 78.3% and 85.3% in the morbidly obese group, and 81.6% and 90.1% in the obese group, respectively. Although the groups’ clinical and pathologic features were homogeneously distributed, disease-free and overall survival rates were significantly different (p=0.053 and p=0.054, respectively). CONCLUSION: Morbidly obese patients with endometrial cancer were associated with 2.7-fold increased risk of death and 1.7-fold increased risk of recurrence compared with those who had body mass index <40 kg/m(2). It is important to deal with the frequent comorbidities in this special group, which could be simply altered by lifestyle changes. Morbidly obese patients with endometrial cancer should be encouraged in lifestyle changes and consulted by dieticians and endocrinologists. Galenos Publishing 2020-09 2020-10-02 /pmc/articles/PMC7538820/ /pubmed/33072426 http://dx.doi.org/10.4274/tjod.galenos.2020.83773 Text en ©Copyright 2020 by Turkish Society of Obstetrics and Gynecology | Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Investigation Güzel, Ahmet Barış Khatib, Ghanim Küçükgöz Güleç, Ümran Gümürdülü, Derya Vardar, Mehmet Ali The impact of morbid obesity on survival of endometrial cancer |
title | The impact of morbid obesity on survival of endometrial cancer |
title_full | The impact of morbid obesity on survival of endometrial cancer |
title_fullStr | The impact of morbid obesity on survival of endometrial cancer |
title_full_unstemmed | The impact of morbid obesity on survival of endometrial cancer |
title_short | The impact of morbid obesity on survival of endometrial cancer |
title_sort | impact of morbid obesity on survival of endometrial cancer |
topic | Clinical Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538820/ https://www.ncbi.nlm.nih.gov/pubmed/33072426 http://dx.doi.org/10.4274/tjod.galenos.2020.83773 |
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