Cargando…

A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression

Chondrosarcomas, malignant cartilaginous neoplasms, are capable of transitioning to highly aggressive, metastatic, and treatment-refractory states, resulting in significant patient mortality. Here, we aim to uncover the transcriptional program directing such tumor progression in chondrosarcomas. We...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Hyeonkyeong, Cho, Yongsik, Kim, Hyeon-Seop, Kang, Donghyun, Cheon, Donghyeon, Kim, Yi-Jun, Chang, Moon Jong, Lee, Kyoung Min, Chang, Chong Bum, Kang, Seung-Baik, Kang, Hyun Guy, Kim, Jin-Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538956/ https://www.ncbi.nlm.nih.gov/pubmed/33024108 http://dx.doi.org/10.1038/s41467-020-18817-7

Ejemplares similares

Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation
por: Kim, Sukyeong, et al.
Publicado: (2019)

Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions
por: Cho, Yongsik, et al.
Publicado: (2021)

Epigenetic Regulation of Chondrocyte Catabolism and Anabolism in Osteoarthritis
por: Kim, Hyeonkyeong, et al.
Publicado: (2015)

CTRP3 exacerbates tendinopathy by dysregulating tendon stem cell differentiation and altering extracellular matrix composition
por: Cho, Yongsik, et al.
Publicado: (2021)

Effects of preoperative, scheduled administration of antiemetics in reducing postoperative nausea and vomiting in patients undergoing total knee arthroplasty
por: Park, Hyung Jun, et al.
Publicado: (2021)

Enhanced recovery after surgery for major orthopedic surgery: a narrative review
por: Choi, Yun Seong, et al.
Publicado: (2022)

Differences in Resumption of Orthopedic Surgery According to Characteristics of Surgery during COVID-19 Pandemic: National Registry Data
por: Park, Hyung Jun, et al.
Publicado: (2023)

A randomized controlled trial for comparing efficacy and safety between intraarticular polynucleotide and hyaluronic acid for knee osteoarthritis treatment
por: Kim, Tae Woo, et al.
Publicado: (2023)

Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis
por: Kang, Donghyun, et al.
Publicado: (2022)

Effect of severity and cause of preoperative anemia on the transfusion rate after total knee arthroplasty
por: Kim, Tae Woo, et al.
Publicado: (2022)

HIF1α-mediated TRAIL Expression Regulates Lacrimal Gland Inflammation in Dry Eye Disease
por: Ji, Yong Woo, et al.
Publicado: (2020)

Prevalence of Osteoporosis in Female Patients with Advanced Knee Osteoarthritis Undergoing Total Knee Arthroplasty
por: Chang, Chong Bum, et al.
Publicado: (2014)

Factors associated with knee pain in 5148 women aged 50 years and older: A population-based study
por: Lee, Kyoung Min, et al.
Publicado: (2018)

Inhibition of HIF-1α by Atorvastatin During (131)I-RTX Therapy in Burkitt’s Lymphoma Model
por: Kim, Eun-Ho, et al.
Publicado: (2020)

Does the severity or cause of preoperative stiffness affect the clinical results and range of motion after total knee arthroplasty?
por: Lee, Seung Ah, et al.
Publicado: (2018)

Management and clinical outcomes of periprosthetic fractures after total knee arthroplasty with a stem extension
por: Shin, Jae Hoon, et al.
Publicado: (2019)

Comparative Analysis of T-Score Discordance between a Registry-Based Korean Population and Atypical Femoral Fracture Patients of a Single Institution
por: Choi, Yun Seong, et al.
Publicado: (2022)

Patterns and Distribution of Deep Vein Thrombosis and Its Effects on Clinical Outcomes After Opening-Wedge High Tibial Osteotomy
por: Park, Hyung Jun, et al.
Publicado: (2021)

Methylglyoxal-Induced Dysfunction in Brain Endothelial Cells via the Suppression of Akt/HIF-1α Pathway and Activation of Mitophagy Associated with Increased Reactive Oxygen Species
por: Kim, Donghyun, et al.
Publicado: (2020)

Suppression of Akt-HIF-1α signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis
por: Choi, Sik-Won, et al.
Publicado: (2016)

Assessment of Anterolateral Ligament of the Knee After Primary Versus Revision Anterior Cruciate Ligament Reconstruction
por: Suh, Dongwhan, et al.
Publicado: (2021)

Increased Expression of Thymosin β(4) Is Independently Correlated with Hypoxia Inducible Factor-1α (HIF-1α) and Worse Clinical Outcome in Human Colorectal Cancer
por: Lee, Seung Yun, et al.
Publicado: (2017)

Variations in sagittal locations of anterior cruciate ligament tibial footprints and their association with radiographic landmarks: a human cadaveric study
por: Cho, Hyung Joon, et al.
Publicado: (2017)

Retrospective study of relationship between vastus medialis volume on SPECT-CT and outcome of unilateral total knee arthroplasty
por: Kim, Hyeong Jik, et al.
Publicado: (2021)

Temporal Value of C-Reactive Protein and Erythrocyte Sedimentation Rate after Total Knee Arthroplasty in Patients with Elevated Preoperative C-Reactive Protein: A Matched-Pair Analysis
por: Lee, Seung Ah, et al.
Publicado: (2019)

Volume-based metabolic parameter of breast cancer on preoperative (18)F-FDG PET/CT could predict axillary lymph node metastasis
por: An, Young-Sil, et al.
Publicado: (2017)

Mesenchymal chondrosarcoma of the hyoid bone: a case report.
por: Joo, M., et al.
Publicado: (1998)

Biomarkers of chondrosarcoma
por: Jeong, Wonju, et al.
Publicado: (2018)

Chondrosarcoma of the Heart
por: Kim, Do Jung, et al.
Publicado: (2015)

Histologic Grade and Decrease in Tumor Dimensions Affect Axillary Lymph Node Status after Neoadjuvant Chemotherapy in Breast Cancer Patients
por: Kim, Tae Hee, et al.
Publicado: (2015)

IDH1 Mutation Induces HIF-1α and Confers Angiogenic Properties in Chondrosarcoma JJ012 Cells
por: Hu, Xiaoyu, et al.
Publicado: (2022)

Worse outcome of debridement, antibiotics, and implant retention in acute hematogenous infections than in postsurgical infections after total knee arthroplasty: a multicenter study
por: Chang, Moon Jong, et al.
Publicado: (2022)

A retrospective comparative study of infection control rate and clinical outcome between open debridement using antibiotic-impregnated cement beads and a two-stage revision in acute periprosthetic knee joint infection
por: Chang, Moon Jong, et al.
Publicado: (2020)

Association of Gap Healing With Angle of Correction After Opening-Wedge High Tibial Osteotomy Without Bone Grafting
por: Park, Hyung Jun, et al.
Publicado: (2021)

The Actin-Sequestering Protein Thymosin Beta-4 Is a Novel Target of Hypoxia-Inducible Nitric Oxide and HIF-1α Regulation
por: Ryu, Yun-Kyoung, et al.
Publicado: (2014)

Assessment of a novel deep learning-based software developed for automatic feature extraction and grading of radiographic knee osteoarthritis
por: Yoon, Ji Soo, et al.
Publicado: (2023)

Hypoxia Antagonizes Glucose Deprivation on Interleukin 6 Expression in an Akt Dependent, but HIF-1/2α Independent Manner
por: Choi, Sung Ji, et al.
Publicado: (2013)

Intracranial Extraskeletal Myxoid Chondrosarcoma : Case Report and Literature Review
por: Park, Jin Hoon, et al.
Publicado: (2012)

Severe Hypocalcemia in a Patient with Recurrent Chondrosarcoma
por: Eun, Jung Nam, et al.
Publicado: (2017)

Incidence of deep vein thrombosis before and after total knee arthroplasty without pharmacologic prophylaxis: a 128-row multidetector CT indirect venography study
por: Chang, Moon Jong, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_63qqs1lbjcn49f0e2dqf42hgk4