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Long-term follow-up of lateral ventricular central neurocytoma treated with subtotal resection followed by concurrent chemoradiotherapy and add on chemotherapy – Case report from a Tertiary Kenyan Cancer Hospital
BACKGROUND: Central neurocytomas are rare, mostly benign neuroectodermal tumors of the central nervous system typically located within the lateral and third ventricles of cerebrum. No consensus guidelines for the management of central neurocytoma available due to the rarity of the disease. CASE DESC...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Scientific Scholar
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538959/ https://www.ncbi.nlm.nih.gov/pubmed/33033634 http://dx.doi.org/10.25259/SNI_389_2020 |
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author | Narayanan, Vijayakumar Julius, Kiboi Mbogo, James |
author_facet | Narayanan, Vijayakumar Julius, Kiboi Mbogo, James |
author_sort | Narayanan, Vijayakumar |
collection | PubMed |
description | BACKGROUND: Central neurocytomas are rare, mostly benign neuroectodermal tumors of the central nervous system typically located within the lateral and third ventricles of cerebrum. No consensus guidelines for the management of central neurocytoma available due to the rarity of the disease. CASE DESCRIPTION: We report a case of right ventricular central neurocytoma of a 28-year-old lady who had a subtotal resection and ventriculoperitoneal shunting. Postoperatively, she was treated with concomitant chemotherapy with oral temozolomide and radiotherapy, followed by add-on chemotherapy with same drug. Imaging, microscopic evaluation, treatment modalities, and outcome of treatment are presented. CONCLUSION: Subtotal resection of tumor through transcallosal approach and ventriculoperitoneal shunt was performed. Imaging done 2 weeks postsurgery confirmed residual disease. Concurrent chemoradiotherapy (54 Gy in 30 fractions +Oral Temozolomide 75 mg/m(2) daily), followed by six cycles of 5-day chemotherapy with temozolomide (150 mg/m(2) in Cycle 1, and 175 mg/m(2) in subsequent cycles) at 28-day intervals, was given. No major toxicities encountered. Follow-up scan after 36 months showed complete remission. |
format | Online Article Text |
id | pubmed-7538959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Scientific Scholar |
record_format | MEDLINE/PubMed |
spelling | pubmed-75389592020-10-07 Long-term follow-up of lateral ventricular central neurocytoma treated with subtotal resection followed by concurrent chemoradiotherapy and add on chemotherapy – Case report from a Tertiary Kenyan Cancer Hospital Narayanan, Vijayakumar Julius, Kiboi Mbogo, James Surg Neurol Int Case Report BACKGROUND: Central neurocytomas are rare, mostly benign neuroectodermal tumors of the central nervous system typically located within the lateral and third ventricles of cerebrum. No consensus guidelines for the management of central neurocytoma available due to the rarity of the disease. CASE DESCRIPTION: We report a case of right ventricular central neurocytoma of a 28-year-old lady who had a subtotal resection and ventriculoperitoneal shunting. Postoperatively, she was treated with concomitant chemotherapy with oral temozolomide and radiotherapy, followed by add-on chemotherapy with same drug. Imaging, microscopic evaluation, treatment modalities, and outcome of treatment are presented. CONCLUSION: Subtotal resection of tumor through transcallosal approach and ventriculoperitoneal shunt was performed. Imaging done 2 weeks postsurgery confirmed residual disease. Concurrent chemoradiotherapy (54 Gy in 30 fractions +Oral Temozolomide 75 mg/m(2) daily), followed by six cycles of 5-day chemotherapy with temozolomide (150 mg/m(2) in Cycle 1, and 175 mg/m(2) in subsequent cycles) at 28-day intervals, was given. No major toxicities encountered. Follow-up scan after 36 months showed complete remission. Scientific Scholar 2020-09-05 /pmc/articles/PMC7538959/ /pubmed/33033634 http://dx.doi.org/10.25259/SNI_389_2020 Text en Copyright: © 2020 Surgical Neurology International http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Narayanan, Vijayakumar Julius, Kiboi Mbogo, James Long-term follow-up of lateral ventricular central neurocytoma treated with subtotal resection followed by concurrent chemoradiotherapy and add on chemotherapy – Case report from a Tertiary Kenyan Cancer Hospital |
title | Long-term follow-up of lateral ventricular central neurocytoma treated with subtotal resection followed by concurrent chemoradiotherapy and add on chemotherapy – Case report from a Tertiary Kenyan Cancer Hospital |
title_full | Long-term follow-up of lateral ventricular central neurocytoma treated with subtotal resection followed by concurrent chemoradiotherapy and add on chemotherapy – Case report from a Tertiary Kenyan Cancer Hospital |
title_fullStr | Long-term follow-up of lateral ventricular central neurocytoma treated with subtotal resection followed by concurrent chemoradiotherapy and add on chemotherapy – Case report from a Tertiary Kenyan Cancer Hospital |
title_full_unstemmed | Long-term follow-up of lateral ventricular central neurocytoma treated with subtotal resection followed by concurrent chemoradiotherapy and add on chemotherapy – Case report from a Tertiary Kenyan Cancer Hospital |
title_short | Long-term follow-up of lateral ventricular central neurocytoma treated with subtotal resection followed by concurrent chemoradiotherapy and add on chemotherapy – Case report from a Tertiary Kenyan Cancer Hospital |
title_sort | long-term follow-up of lateral ventricular central neurocytoma treated with subtotal resection followed by concurrent chemoradiotherapy and add on chemotherapy – case report from a tertiary kenyan cancer hospital |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538959/ https://www.ncbi.nlm.nih.gov/pubmed/33033634 http://dx.doi.org/10.25259/SNI_389_2020 |
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