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Cognitive differences associated with HIV serostatus and antiretroviral therapy use in a population-based sample of older adults in South Africa
Previous clinical studies have reported adverse cognitive outcomes for people living with HIV (PLWH), but there are no population-based studies comparing cognitive function between older PLWH and comparators without HIV in sub-Saharan Africa. We analyzed baseline data of 40 + years-old participants...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539005/ https://www.ncbi.nlm.nih.gov/pubmed/33024208 http://dx.doi.org/10.1038/s41598-020-73689-7 |
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author | Asiimwe, Stephen B. Farrell, Meagan Kobayashi, Lindsay C. Manne-Goehler, Jen Kahn, Kathleen Tollman, Stephen M. Kabudula, Chodziwadziwa Whiteson Gómez-Olivé, F. Xavier Wagner, Ryan G. Montana, Livia Berkman, Lisa F. Glymour, M. Maria Bärnighausen, Till |
author_facet | Asiimwe, Stephen B. Farrell, Meagan Kobayashi, Lindsay C. Manne-Goehler, Jen Kahn, Kathleen Tollman, Stephen M. Kabudula, Chodziwadziwa Whiteson Gómez-Olivé, F. Xavier Wagner, Ryan G. Montana, Livia Berkman, Lisa F. Glymour, M. Maria Bärnighausen, Till |
author_sort | Asiimwe, Stephen B. |
collection | PubMed |
description | Previous clinical studies have reported adverse cognitive outcomes for people living with HIV (PLWH), but there are no population-based studies comparing cognitive function between older PLWH and comparators without HIV in sub-Saharan Africa. We analyzed baseline data of 40 + years-old participants in “Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa” (HAALSI) cohort. We measured cognition using a battery of conventional instruments assessing orientation, immediate- and delayed-recall, and numeracy (N = 4560), and the Oxford Cognitive Screen [OCS]-Plus, a novel instrument for low-literacy populations, assessing memory, language, visual-spatial ability, and executive functioning (N = 1997). Linear regression models comparing cognitive scores between participants with and without HIV were adjusted for sex, education, age, country of birth, father’s occupation, ever-consumed alcohol, and asset index. PLWH scored on average 0.06 (95% CI 0.01–0.12) standard deviation (SD) units higher on the conventional cognitive function measure and 0.02 (95% CI − 0.07 to 0.04) SD units lower on the OCS-Plus measure than HIV-negative participants. We found higher cognitive function scores for PLWH compared to people without HIV when using a conventional measure of cognitive function but not when using a novel instrument for low-literacy settings. |
format | Online Article Text |
id | pubmed-7539005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-75390052020-10-08 Cognitive differences associated with HIV serostatus and antiretroviral therapy use in a population-based sample of older adults in South Africa Asiimwe, Stephen B. Farrell, Meagan Kobayashi, Lindsay C. Manne-Goehler, Jen Kahn, Kathleen Tollman, Stephen M. Kabudula, Chodziwadziwa Whiteson Gómez-Olivé, F. Xavier Wagner, Ryan G. Montana, Livia Berkman, Lisa F. Glymour, M. Maria Bärnighausen, Till Sci Rep Article Previous clinical studies have reported adverse cognitive outcomes for people living with HIV (PLWH), but there are no population-based studies comparing cognitive function between older PLWH and comparators without HIV in sub-Saharan Africa. We analyzed baseline data of 40 + years-old participants in “Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa” (HAALSI) cohort. We measured cognition using a battery of conventional instruments assessing orientation, immediate- and delayed-recall, and numeracy (N = 4560), and the Oxford Cognitive Screen [OCS]-Plus, a novel instrument for low-literacy populations, assessing memory, language, visual-spatial ability, and executive functioning (N = 1997). Linear regression models comparing cognitive scores between participants with and without HIV were adjusted for sex, education, age, country of birth, father’s occupation, ever-consumed alcohol, and asset index. PLWH scored on average 0.06 (95% CI 0.01–0.12) standard deviation (SD) units higher on the conventional cognitive function measure and 0.02 (95% CI − 0.07 to 0.04) SD units lower on the OCS-Plus measure than HIV-negative participants. We found higher cognitive function scores for PLWH compared to people without HIV when using a conventional measure of cognitive function but not when using a novel instrument for low-literacy settings. Nature Publishing Group UK 2020-10-06 /pmc/articles/PMC7539005/ /pubmed/33024208 http://dx.doi.org/10.1038/s41598-020-73689-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Asiimwe, Stephen B. Farrell, Meagan Kobayashi, Lindsay C. Manne-Goehler, Jen Kahn, Kathleen Tollman, Stephen M. Kabudula, Chodziwadziwa Whiteson Gómez-Olivé, F. Xavier Wagner, Ryan G. Montana, Livia Berkman, Lisa F. Glymour, M. Maria Bärnighausen, Till Cognitive differences associated with HIV serostatus and antiretroviral therapy use in a population-based sample of older adults in South Africa |
title | Cognitive differences associated with HIV serostatus and antiretroviral therapy use in a population-based sample of older adults in South Africa |
title_full | Cognitive differences associated with HIV serostatus and antiretroviral therapy use in a population-based sample of older adults in South Africa |
title_fullStr | Cognitive differences associated with HIV serostatus and antiretroviral therapy use in a population-based sample of older adults in South Africa |
title_full_unstemmed | Cognitive differences associated with HIV serostatus and antiretroviral therapy use in a population-based sample of older adults in South Africa |
title_short | Cognitive differences associated with HIV serostatus and antiretroviral therapy use in a population-based sample of older adults in South Africa |
title_sort | cognitive differences associated with hiv serostatus and antiretroviral therapy use in a population-based sample of older adults in south africa |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539005/ https://www.ncbi.nlm.nih.gov/pubmed/33024208 http://dx.doi.org/10.1038/s41598-020-73689-7 |
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