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Comparative Study of the Effects of 1% Atropine on the Anterior Segment

PURPOSE: To investigate the influences of atropine on changes in anterior segment geometry, as measured by ultrasound biomicroscopy in children. METHODS: A prospective observational study was performed. Anterior segment parameters were obtained by UBM before and after the instillation of 1% atropine...

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Autores principales: Zhou, Yue, Huang, Xiao Bo, Cai, Qi, Li, Jun Jie, Xiong, Yao Jia, Gong, Ye Xun, Lin, Li Wei, Zhu, Yan, Sun, Zhi Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539084/
https://www.ncbi.nlm.nih.gov/pubmed/33062312
http://dx.doi.org/10.1155/2020/5125243
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author Zhou, Yue
Huang, Xiao Bo
Cai, Qi
Li, Jun Jie
Xiong, Yao Jia
Gong, Ye Xun
Lin, Li Wei
Zhu, Yan
Sun, Zhi Min
author_facet Zhou, Yue
Huang, Xiao Bo
Cai, Qi
Li, Jun Jie
Xiong, Yao Jia
Gong, Ye Xun
Lin, Li Wei
Zhu, Yan
Sun, Zhi Min
author_sort Zhou, Yue
collection PubMed
description PURPOSE: To investigate the influences of atropine on changes in anterior segment geometry, as measured by ultrasound biomicroscopy in children. METHODS: A prospective observational study was performed. Anterior segment parameters were obtained by UBM before and after the instillation of 1% atropine. Univariate linear regression was performed to identify the variables contributing to the changes in the trabecular meshwork-iris angle (TIA). RESULTS: The study included 21 boys and 37 girls with a mean age of 10.79 ± 2.53 years. Anterior chamber parameters including the central anterior chamber depth, TIA, angle opening distance at 500 μm from the scleral spur, iris thickness 750 μm and 1500 μm from the scleral spur, trabecular-ciliary angle (TCA), trabecular-ciliary process distance, sclera-iris angle (SIA), and sclera-ciliary process angle significantly increased after cycloplegia (P < 0.05). In contrast, the lens vault, iris cross-sectional area, and maximum ciliary muscle thickness significantly decreased after cycloplegia. Univariate analysis identified the change in TCA and the change in SIA and the TIA before mydriasis as determinants of the change in TIA. CONCLUSIONS: Atropine causes statistically significant changes in various anterior segment parameters in children. The change in anterior chamber angle is associated with the change in TCA and the change in SIA and the TIA before mydriasis.
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spelling pubmed-75390842020-10-13 Comparative Study of the Effects of 1% Atropine on the Anterior Segment Zhou, Yue Huang, Xiao Bo Cai, Qi Li, Jun Jie Xiong, Yao Jia Gong, Ye Xun Lin, Li Wei Zhu, Yan Sun, Zhi Min J Ophthalmol Clinical Study PURPOSE: To investigate the influences of atropine on changes in anterior segment geometry, as measured by ultrasound biomicroscopy in children. METHODS: A prospective observational study was performed. Anterior segment parameters were obtained by UBM before and after the instillation of 1% atropine. Univariate linear regression was performed to identify the variables contributing to the changes in the trabecular meshwork-iris angle (TIA). RESULTS: The study included 21 boys and 37 girls with a mean age of 10.79 ± 2.53 years. Anterior chamber parameters including the central anterior chamber depth, TIA, angle opening distance at 500 μm from the scleral spur, iris thickness 750 μm and 1500 μm from the scleral spur, trabecular-ciliary angle (TCA), trabecular-ciliary process distance, sclera-iris angle (SIA), and sclera-ciliary process angle significantly increased after cycloplegia (P < 0.05). In contrast, the lens vault, iris cross-sectional area, and maximum ciliary muscle thickness significantly decreased after cycloplegia. Univariate analysis identified the change in TCA and the change in SIA and the TIA before mydriasis as determinants of the change in TIA. CONCLUSIONS: Atropine causes statistically significant changes in various anterior segment parameters in children. The change in anterior chamber angle is associated with the change in TCA and the change in SIA and the TIA before mydriasis. Hindawi 2020-09-28 /pmc/articles/PMC7539084/ /pubmed/33062312 http://dx.doi.org/10.1155/2020/5125243 Text en Copyright © 2020 Yue Zhou et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Zhou, Yue
Huang, Xiao Bo
Cai, Qi
Li, Jun Jie
Xiong, Yao Jia
Gong, Ye Xun
Lin, Li Wei
Zhu, Yan
Sun, Zhi Min
Comparative Study of the Effects of 1% Atropine on the Anterior Segment
title Comparative Study of the Effects of 1% Atropine on the Anterior Segment
title_full Comparative Study of the Effects of 1% Atropine on the Anterior Segment
title_fullStr Comparative Study of the Effects of 1% Atropine on the Anterior Segment
title_full_unstemmed Comparative Study of the Effects of 1% Atropine on the Anterior Segment
title_short Comparative Study of the Effects of 1% Atropine on the Anterior Segment
title_sort comparative study of the effects of 1% atropine on the anterior segment
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539084/
https://www.ncbi.nlm.nih.gov/pubmed/33062312
http://dx.doi.org/10.1155/2020/5125243
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