Cargando…

Clinical characteristics and risk factors of liver injury in COVID-19: a retrospective cohort study from Wuhan, China

BACKGROUND: Coronavirus disease 2019 (COVID-19) has rapidly become a major international public health concern. This study was designed to evaluate the clinical characteristics and risk factors of COVID-19-associated liver injury. METHODS: A fraction of 657 COVID-19 patients were retrospectively ana...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Ming, Yan, Weiming, Qi, Weipeng, Wu, Di, Zhu, Lin, Li, Weina, Wang, Xiaojing, Ma, Ke, Ni, Ming, Xu, Dong, Wang, Hongwu, Chen, Guang, Yu, Haijing, Ding, Hongfang, Xing, Mingyou, Han, Meifang, Luo, Xiaoping, Chen, Tao, Guo, Wei, Xi, Dong, Ning, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539280/
https://www.ncbi.nlm.nih.gov/pubmed/33026573
http://dx.doi.org/10.1007/s12072-020-10075-5
_version_ 1783591027135741952
author Wang, Ming
Yan, Weiming
Qi, Weipeng
Wu, Di
Zhu, Lin
Li, Weina
Wang, Xiaojing
Ma, Ke
Ni, Ming
Xu, Dong
Wang, Hongwu
Chen, Guang
Yu, Haijing
Ding, Hongfang
Xing, Mingyou
Han, Meifang
Luo, Xiaoping
Chen, Tao
Guo, Wei
Xi, Dong
Ning, Qin
author_facet Wang, Ming
Yan, Weiming
Qi, Weipeng
Wu, Di
Zhu, Lin
Li, Weina
Wang, Xiaojing
Ma, Ke
Ni, Ming
Xu, Dong
Wang, Hongwu
Chen, Guang
Yu, Haijing
Ding, Hongfang
Xing, Mingyou
Han, Meifang
Luo, Xiaoping
Chen, Tao
Guo, Wei
Xi, Dong
Ning, Qin
author_sort Wang, Ming
collection PubMed
description BACKGROUND: Coronavirus disease 2019 (COVID-19) has rapidly become a major international public health concern. This study was designed to evaluate the clinical characteristics and risk factors of COVID-19-associated liver injury. METHODS: A fraction of 657 COVID-19 patients were retrospectively analyzed. Clinical and laboratory data were derived from electronic medical records and compared between patients with or without liver injury. Multivariate logistic regression method was used to analyze the risk factors for liver injury. RESULTS: Among 657 patients, 303 (46.1%) patients had liver injury with higher rate in severe/critically ill patients [148/257 (57.6%)] than those in moderate cases [155/400 (38.8%)]. The incidence of liver injury was much higher in male [192/303 (63.4%)] than female [111/303 (36.6%)], and in severe/critical patients [148/303 (48.8%)] with percutaneous oxygen saturation ≤ 93% [89/279 (31.9%)] or peak body temperature ≥ 38.5 °C [185/301 (61.5%)] on admission. Liver injury-related inflammations included increased white blood cells, neutrophils and decreased lymphocytes. More patients with liver injury than without had increased serum IL-2R, TNFα, ferritin, hsCRP, PCT, ESR, γ-GT, and LDH. Multivariate regression analysis revealed that increasing odds of liver injury were related to male, higher serum hsCRP (≥ 10 mg/L), and neutrophil-to-lymphocyte ratio (NLR) (≥ 5). Moreover, more deceased patients (14/82 (17%)) had significantly elevated serum TBIL than discharged patients [25/532 (4.7%)]. CONCLUSION: Liver injury is a common complication in COVID-19 patients. The potential risk factors of liver injury include male, hsCRP and NLR score. A close monitor of liver function should be warned in COVID-19 patients, especially in severe/critical individuals. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12072-020-10075-5) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-7539280
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer India
record_format MEDLINE/PubMed
spelling pubmed-75392802020-10-07 Clinical characteristics and risk factors of liver injury in COVID-19: a retrospective cohort study from Wuhan, China Wang, Ming Yan, Weiming Qi, Weipeng Wu, Di Zhu, Lin Li, Weina Wang, Xiaojing Ma, Ke Ni, Ming Xu, Dong Wang, Hongwu Chen, Guang Yu, Haijing Ding, Hongfang Xing, Mingyou Han, Meifang Luo, Xiaoping Chen, Tao Guo, Wei Xi, Dong Ning, Qin Hepatol Int Original Article BACKGROUND: Coronavirus disease 2019 (COVID-19) has rapidly become a major international public health concern. This study was designed to evaluate the clinical characteristics and risk factors of COVID-19-associated liver injury. METHODS: A fraction of 657 COVID-19 patients were retrospectively analyzed. Clinical and laboratory data were derived from electronic medical records and compared between patients with or without liver injury. Multivariate logistic regression method was used to analyze the risk factors for liver injury. RESULTS: Among 657 patients, 303 (46.1%) patients had liver injury with higher rate in severe/critically ill patients [148/257 (57.6%)] than those in moderate cases [155/400 (38.8%)]. The incidence of liver injury was much higher in male [192/303 (63.4%)] than female [111/303 (36.6%)], and in severe/critical patients [148/303 (48.8%)] with percutaneous oxygen saturation ≤ 93% [89/279 (31.9%)] or peak body temperature ≥ 38.5 °C [185/301 (61.5%)] on admission. Liver injury-related inflammations included increased white blood cells, neutrophils and decreased lymphocytes. More patients with liver injury than without had increased serum IL-2R, TNFα, ferritin, hsCRP, PCT, ESR, γ-GT, and LDH. Multivariate regression analysis revealed that increasing odds of liver injury were related to male, higher serum hsCRP (≥ 10 mg/L), and neutrophil-to-lymphocyte ratio (NLR) (≥ 5). Moreover, more deceased patients (14/82 (17%)) had significantly elevated serum TBIL than discharged patients [25/532 (4.7%)]. CONCLUSION: Liver injury is a common complication in COVID-19 patients. The potential risk factors of liver injury include male, hsCRP and NLR score. A close monitor of liver function should be warned in COVID-19 patients, especially in severe/critical individuals. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12072-020-10075-5) contains supplementary material, which is available to authorized users. Springer India 2020-10-07 /pmc/articles/PMC7539280/ /pubmed/33026573 http://dx.doi.org/10.1007/s12072-020-10075-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Wang, Ming
Yan, Weiming
Qi, Weipeng
Wu, Di
Zhu, Lin
Li, Weina
Wang, Xiaojing
Ma, Ke
Ni, Ming
Xu, Dong
Wang, Hongwu
Chen, Guang
Yu, Haijing
Ding, Hongfang
Xing, Mingyou
Han, Meifang
Luo, Xiaoping
Chen, Tao
Guo, Wei
Xi, Dong
Ning, Qin
Clinical characteristics and risk factors of liver injury in COVID-19: a retrospective cohort study from Wuhan, China
title Clinical characteristics and risk factors of liver injury in COVID-19: a retrospective cohort study from Wuhan, China
title_full Clinical characteristics and risk factors of liver injury in COVID-19: a retrospective cohort study from Wuhan, China
title_fullStr Clinical characteristics and risk factors of liver injury in COVID-19: a retrospective cohort study from Wuhan, China
title_full_unstemmed Clinical characteristics and risk factors of liver injury in COVID-19: a retrospective cohort study from Wuhan, China
title_short Clinical characteristics and risk factors of liver injury in COVID-19: a retrospective cohort study from Wuhan, China
title_sort clinical characteristics and risk factors of liver injury in covid-19: a retrospective cohort study from wuhan, china
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539280/
https://www.ncbi.nlm.nih.gov/pubmed/33026573
http://dx.doi.org/10.1007/s12072-020-10075-5
work_keys_str_mv AT wangming clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT yanweiming clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT qiweipeng clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT wudi clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT zhulin clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT liweina clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT wangxiaojing clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT make clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT niming clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT xudong clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT wanghongwu clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT chenguang clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT yuhaijing clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT dinghongfang clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT xingmingyou clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT hanmeifang clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT luoxiaoping clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT chentao clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT guowei clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT xidong clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina
AT ningqin clinicalcharacteristicsandriskfactorsofliverinjuryincovid19aretrospectivecohortstudyfromwuhanchina