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Isochronal Conditions—The Key To Maintain the Given Solubility Limit, of a Small Molecule within the Polymer Matrix, at Elevated Pressure
[Image: see text] In this work, we proposed the method to maintain the desired level of drug’s solubility within the polymer matrix by adjusting conditions to uphold the same molecular dynamics of the system (e.g., temperature for set elevated pressure or vice versa). Namely, we observed, that recry...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539297/ https://www.ncbi.nlm.nih.gov/pubmed/32790413 http://dx.doi.org/10.1021/acs.molpharmaceut.0c00463 |
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author | Chmiel, Krzysztof Knapik-Kowalczuk, Justyna Paluch, Marian |
author_facet | Chmiel, Krzysztof Knapik-Kowalczuk, Justyna Paluch, Marian |
author_sort | Chmiel, Krzysztof |
collection | PubMed |
description | [Image: see text] In this work, we proposed the method to maintain the desired level of drug’s solubility within the polymer matrix by adjusting conditions to uphold the same molecular dynamics of the system (e.g., temperature for set elevated pressure or vice versa). Namely, we observed, that recrystallization of the drug from the supersaturated drug–polymer system, initiated for the same structural relaxation time of the sample (τ(α-1)) ceases when certain, different than the initial, molecular mobility of the systems is reached (τ(α-2))—regardless of a given combination of temperature and pressure conditions. Based on the presented results, one can conclude that the molecular dynamics seem to control the process of recrystallization of the excess amount of solute from the supersaturated solution (e.g., small molecules dissolved within the polymer). Therefore, it appears that the elevated pressure compensates the effect of solubility enhancement caused by the elevated temperature. Such information not only is of fundamental relevance in science but also, from a much broader perspective, could be potentially very useful considering extrusion-based manufacturing methods. |
format | Online Article Text |
id | pubmed-7539297 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Chemical
Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-75392972020-10-07 Isochronal Conditions—The Key To Maintain the Given Solubility Limit, of a Small Molecule within the Polymer Matrix, at Elevated Pressure Chmiel, Krzysztof Knapik-Kowalczuk, Justyna Paluch, Marian Mol Pharm [Image: see text] In this work, we proposed the method to maintain the desired level of drug’s solubility within the polymer matrix by adjusting conditions to uphold the same molecular dynamics of the system (e.g., temperature for set elevated pressure or vice versa). Namely, we observed, that recrystallization of the drug from the supersaturated drug–polymer system, initiated for the same structural relaxation time of the sample (τ(α-1)) ceases when certain, different than the initial, molecular mobility of the systems is reached (τ(α-2))—regardless of a given combination of temperature and pressure conditions. Based on the presented results, one can conclude that the molecular dynamics seem to control the process of recrystallization of the excess amount of solute from the supersaturated solution (e.g., small molecules dissolved within the polymer). Therefore, it appears that the elevated pressure compensates the effect of solubility enhancement caused by the elevated temperature. Such information not only is of fundamental relevance in science but also, from a much broader perspective, could be potentially very useful considering extrusion-based manufacturing methods. American Chemical Society 2020-08-13 2020-10-05 /pmc/articles/PMC7539297/ /pubmed/32790413 http://dx.doi.org/10.1021/acs.molpharmaceut.0c00463 Text en This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. |
spellingShingle | Chmiel, Krzysztof Knapik-Kowalczuk, Justyna Paluch, Marian Isochronal Conditions—The Key To Maintain the Given Solubility Limit, of a Small Molecule within the Polymer Matrix, at Elevated Pressure |
title | Isochronal Conditions—The Key To Maintain the
Given Solubility Limit, of a Small Molecule within the Polymer Matrix,
at Elevated Pressure |
title_full | Isochronal Conditions—The Key To Maintain the
Given Solubility Limit, of a Small Molecule within the Polymer Matrix,
at Elevated Pressure |
title_fullStr | Isochronal Conditions—The Key To Maintain the
Given Solubility Limit, of a Small Molecule within the Polymer Matrix,
at Elevated Pressure |
title_full_unstemmed | Isochronal Conditions—The Key To Maintain the
Given Solubility Limit, of a Small Molecule within the Polymer Matrix,
at Elevated Pressure |
title_short | Isochronal Conditions—The Key To Maintain the
Given Solubility Limit, of a Small Molecule within the Polymer Matrix,
at Elevated Pressure |
title_sort | isochronal conditions—the key to maintain the
given solubility limit, of a small molecule within the polymer matrix,
at elevated pressure |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539297/ https://www.ncbi.nlm.nih.gov/pubmed/32790413 http://dx.doi.org/10.1021/acs.molpharmaceut.0c00463 |
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