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Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection

BACKGROUND: This study aimed to assess the prognostic factors including low skeletal muscle mass index (SMI) and perioperative blood transfusion for patients with hepatocellular carcinoma (HCC) following curative surgery. METHODS: This study included 139 patients with HCC who underwent hepatectomy b...

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Autores principales: Bekki, Tomoaki, Abe, Tomoyuki, Amano, Hironobu, Hattori, Minoru, Kobayashi, Tsuyoshi, Nakahara, Masahiro, Ohdan, Hideki, Noriyuki, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539410/
https://www.ncbi.nlm.nih.gov/pubmed/33028209
http://dx.doi.org/10.1186/s12876-020-01472-z
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author Bekki, Tomoaki
Abe, Tomoyuki
Amano, Hironobu
Hattori, Minoru
Kobayashi, Tsuyoshi
Nakahara, Masahiro
Ohdan, Hideki
Noriyuki, Toshio
author_facet Bekki, Tomoaki
Abe, Tomoyuki
Amano, Hironobu
Hattori, Minoru
Kobayashi, Tsuyoshi
Nakahara, Masahiro
Ohdan, Hideki
Noriyuki, Toshio
author_sort Bekki, Tomoaki
collection PubMed
description BACKGROUND: This study aimed to assess the prognostic factors including low skeletal muscle mass index (SMI) and perioperative blood transfusion for patients with hepatocellular carcinoma (HCC) following curative surgery. METHODS: This study included 139 patients with HCC who underwent hepatectomy between 2005 and 2016. Univariate and multivariate analyses were performed to identify variables associated with overall survival (OS) and recurrence-free survival (RFS). RESULTS: Low SMI was significantly related with poor OS, while blood transfusion had a strong impact on RFS. The male ratio and body mass index in the low SMI group were significantly higher than those in the high SMI group. There were no significant differences in age, virus etiology, laboratory data, liver function, tumor makers, and operative variables between the groups. Tumor factors such as tumor diameter, tumor number, poor differentiation, and intrahepatic metastasis (IM) did not significantly differ between the two groups. Operation time, intraoperative blood loss volume, and recurrence ratio were significantly higher in the blood transfusion group than in the non-transfusion group. IM was associated with poor OS and RFS. CONCLUSIONS: Low SMI and blood transfusion were independently related with long-term prognosis in patients with HCC following curative surgery.
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spelling pubmed-75394102020-10-08 Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection Bekki, Tomoaki Abe, Tomoyuki Amano, Hironobu Hattori, Minoru Kobayashi, Tsuyoshi Nakahara, Masahiro Ohdan, Hideki Noriyuki, Toshio BMC Gastroenterol Research Article BACKGROUND: This study aimed to assess the prognostic factors including low skeletal muscle mass index (SMI) and perioperative blood transfusion for patients with hepatocellular carcinoma (HCC) following curative surgery. METHODS: This study included 139 patients with HCC who underwent hepatectomy between 2005 and 2016. Univariate and multivariate analyses were performed to identify variables associated with overall survival (OS) and recurrence-free survival (RFS). RESULTS: Low SMI was significantly related with poor OS, while blood transfusion had a strong impact on RFS. The male ratio and body mass index in the low SMI group were significantly higher than those in the high SMI group. There were no significant differences in age, virus etiology, laboratory data, liver function, tumor makers, and operative variables between the groups. Tumor factors such as tumor diameter, tumor number, poor differentiation, and intrahepatic metastasis (IM) did not significantly differ between the two groups. Operation time, intraoperative blood loss volume, and recurrence ratio were significantly higher in the blood transfusion group than in the non-transfusion group. IM was associated with poor OS and RFS. CONCLUSIONS: Low SMI and blood transfusion were independently related with long-term prognosis in patients with HCC following curative surgery. BioMed Central 2020-10-07 /pmc/articles/PMC7539410/ /pubmed/33028209 http://dx.doi.org/10.1186/s12876-020-01472-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Bekki, Tomoaki
Abe, Tomoyuki
Amano, Hironobu
Hattori, Minoru
Kobayashi, Tsuyoshi
Nakahara, Masahiro
Ohdan, Hideki
Noriyuki, Toshio
Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection
title Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection
title_full Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection
title_fullStr Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection
title_full_unstemmed Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection
title_short Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection
title_sort impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for hcc following curative resection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539410/
https://www.ncbi.nlm.nih.gov/pubmed/33028209
http://dx.doi.org/10.1186/s12876-020-01472-z
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