A possible link to uracil DNA glycosylase in the synergistic action of HDAC inhibitors and thymidylate synthase inhibitors

It is well established that thymidylate synthase inhibitors can cause cellular toxicity through uracil DNA glycosylase (UNG2)-dependent pathways. Additionally, thymidylate synthase inhibitors and HDAC inhibitors are known to act synergistically in a variety of cancer types. A recent article from J....

Descripción completa

Detalles Bibliográficos
Autores principales: Showler, Meredith S., Weiser, Brian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539467/
https://www.ncbi.nlm.nih.gov/pubmed/33028332
http://dx.doi.org/10.1186/s12967-020-02555-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539467/
https://www.ncbi.nlm.nih.gov/pubmed/33028332
http://dx.doi.org/10.1186/s12967-020-02555-x

Ejemplares similares