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Do human embryos have the ability of self-correction?
Human embryogenesis frequently coinciding with cell division mistakes contributing to pervasive embryonic aneuploidy/mosaicism. While embryo self-correction was elegantly demonstrated in mouse models, human studies are lacking. Here we are witness to human embryos ability to eliminate/expel abnormal...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539487/ https://www.ncbi.nlm.nih.gov/pubmed/33023576 http://dx.doi.org/10.1186/s12958-020-00650-8 |
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author | Orvieto, Raoul Shimon, Chen Rienstein, Shlomit Jonish-Grossman, Anat Shani, Hagit Aizer, Adva |
author_facet | Orvieto, Raoul Shimon, Chen Rienstein, Shlomit Jonish-Grossman, Anat Shani, Hagit Aizer, Adva |
author_sort | Orvieto, Raoul |
collection | PubMed |
description | Human embryogenesis frequently coinciding with cell division mistakes contributing to pervasive embryonic aneuploidy/mosaicism. While embryo self-correction was elegantly demonstrated in mouse models, human studies are lacking. Here we are witness to human embryos ability to eliminate/expel abnormal blastomeres as cell debris/fragments. Each blastocyst and its corresponding debris were separated and underwent whole genome amplification. Seven of the 11 pairs of blastocysts and their corresponding cell debris/fragments revealed discordant results. Of the 9 euploid blastocysts, four showed euploid debris, while in the others, the debris were aneuploid. In the remaining pairs, the debris showed additional aneuploidy to those presented by their corresponding blastocyst. The observed ability of human embryos to self-correction doubts many invasive and non-invasive preimplantation testing for aneuploidy at the blastocyst stage, rendering high rate of false positive (discarding “good” embryos) by identifying the cell-free DNA originated from the expelled cell debris, as aneuploidy/mosaic blastocyst. |
format | Online Article Text |
id | pubmed-7539487 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-75394872020-10-08 Do human embryos have the ability of self-correction? Orvieto, Raoul Shimon, Chen Rienstein, Shlomit Jonish-Grossman, Anat Shani, Hagit Aizer, Adva Reprod Biol Endocrinol Research Human embryogenesis frequently coinciding with cell division mistakes contributing to pervasive embryonic aneuploidy/mosaicism. While embryo self-correction was elegantly demonstrated in mouse models, human studies are lacking. Here we are witness to human embryos ability to eliminate/expel abnormal blastomeres as cell debris/fragments. Each blastocyst and its corresponding debris were separated and underwent whole genome amplification. Seven of the 11 pairs of blastocysts and their corresponding cell debris/fragments revealed discordant results. Of the 9 euploid blastocysts, four showed euploid debris, while in the others, the debris were aneuploid. In the remaining pairs, the debris showed additional aneuploidy to those presented by their corresponding blastocyst. The observed ability of human embryos to self-correction doubts many invasive and non-invasive preimplantation testing for aneuploidy at the blastocyst stage, rendering high rate of false positive (discarding “good” embryos) by identifying the cell-free DNA originated from the expelled cell debris, as aneuploidy/mosaic blastocyst. BioMed Central 2020-10-06 /pmc/articles/PMC7539487/ /pubmed/33023576 http://dx.doi.org/10.1186/s12958-020-00650-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Orvieto, Raoul Shimon, Chen Rienstein, Shlomit Jonish-Grossman, Anat Shani, Hagit Aizer, Adva Do human embryos have the ability of self-correction? |
title | Do human embryos have the ability of self-correction? |
title_full | Do human embryos have the ability of self-correction? |
title_fullStr | Do human embryos have the ability of self-correction? |
title_full_unstemmed | Do human embryos have the ability of self-correction? |
title_short | Do human embryos have the ability of self-correction? |
title_sort | do human embryos have the ability of self-correction? |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539487/ https://www.ncbi.nlm.nih.gov/pubmed/33023576 http://dx.doi.org/10.1186/s12958-020-00650-8 |
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