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If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?
Because our beliefs regarding our individuality, autonomy, and personhood are intimately bound up with our brains, there is a public fascination with cerebral organoids, the “mini-brain,” the “brain in a dish”. At the same time, the ethical issues around organoids are only now being explored. What a...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539594/ https://www.ncbi.nlm.nih.gov/pubmed/32281909 http://dx.doi.org/10.1177/1073858420912404 |
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author | Ooi, Lezanne Dottori, Mirella Cook, Anthony L. Engel, Martin Gautam, Vini Grubman, Alexandra Hernández, Damián King, Anna E. Maksour, Simon Targa Dias Anastacio, Helena Balez, Rachelle Pébay, Alice Pouton, Colin Valenzuela, Michael White, Anthony Williamson, Robert |
author_facet | Ooi, Lezanne Dottori, Mirella Cook, Anthony L. Engel, Martin Gautam, Vini Grubman, Alexandra Hernández, Damián King, Anna E. Maksour, Simon Targa Dias Anastacio, Helena Balez, Rachelle Pébay, Alice Pouton, Colin Valenzuela, Michael White, Anthony Williamson, Robert |
author_sort | Ooi, Lezanne |
collection | PubMed |
description | Because our beliefs regarding our individuality, autonomy, and personhood are intimately bound up with our brains, there is a public fascination with cerebral organoids, the “mini-brain,” the “brain in a dish”. At the same time, the ethical issues around organoids are only now being explored. What are the prospects of using human cerebral organoids to better understand, treat, or prevent dementia? Will human organoids represent an improvement on the current, less-than-satisfactory, animal models? When considering these questions, two major issues arise. One is the general challenge associated with using any stem cell–generated preparation for in vitro modelling (challenges amplified when using organoids compared with simpler cell culture systems). The other relates to complexities associated with defining and understanding what we mean by the term “dementia.” We discuss 10 puzzles, issues, and stumbling blocks to watch for in the quest to model “dementia in a dish.” |
format | Online Article Text |
id | pubmed-7539594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-75395942020-10-14 If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions? Ooi, Lezanne Dottori, Mirella Cook, Anthony L. Engel, Martin Gautam, Vini Grubman, Alexandra Hernández, Damián King, Anna E. Maksour, Simon Targa Dias Anastacio, Helena Balez, Rachelle Pébay, Alice Pouton, Colin Valenzuela, Michael White, Anthony Williamson, Robert Neuroscientist Reviews Because our beliefs regarding our individuality, autonomy, and personhood are intimately bound up with our brains, there is a public fascination with cerebral organoids, the “mini-brain,” the “brain in a dish”. At the same time, the ethical issues around organoids are only now being explored. What are the prospects of using human cerebral organoids to better understand, treat, or prevent dementia? Will human organoids represent an improvement on the current, less-than-satisfactory, animal models? When considering these questions, two major issues arise. One is the general challenge associated with using any stem cell–generated preparation for in vitro modelling (challenges amplified when using organoids compared with simpler cell culture systems). The other relates to complexities associated with defining and understanding what we mean by the term “dementia.” We discuss 10 puzzles, issues, and stumbling blocks to watch for in the quest to model “dementia in a dish.” SAGE Publications 2020-04-13 2020-10 /pmc/articles/PMC7539594/ /pubmed/32281909 http://dx.doi.org/10.1177/1073858420912404 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Reviews Ooi, Lezanne Dottori, Mirella Cook, Anthony L. Engel, Martin Gautam, Vini Grubman, Alexandra Hernández, Damián King, Anna E. Maksour, Simon Targa Dias Anastacio, Helena Balez, Rachelle Pébay, Alice Pouton, Colin Valenzuela, Michael White, Anthony Williamson, Robert If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions? |
title | If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions? |
title_full | If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions? |
title_fullStr | If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions? |
title_full_unstemmed | If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions? |
title_short | If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions? |
title_sort | if human brain organoids are the answer to understanding dementia, what are the questions? |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539594/ https://www.ncbi.nlm.nih.gov/pubmed/32281909 http://dx.doi.org/10.1177/1073858420912404 |
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