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Effects of lighting variability on locomotion in posterior cortical atrophy
INTRODUCTION: Clinical reports describe patients with Alzheimer's disease (AD) exhibiting atypical adaptive walking responses to the visual environment; however, there is limited empirical investigation of such behaviors or factors modulating their expression. We aim to evaluate effects of ligh...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539669/ https://www.ncbi.nlm.nih.gov/pubmed/33043109 http://dx.doi.org/10.1002/trc2.12077 |
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author | Yong, Keir X. X. McCarthy, Ian D. Poole, Teresa Ocal, Dilek Suzuki, Ayako Suzuki, Tatsuto Mengoudi, Kyriaki Papadosifos, Nikolaos Boampong, Derrick Tyler, Nick Frost, Chris Crutch, Sebastian J. |
author_facet | Yong, Keir X. X. McCarthy, Ian D. Poole, Teresa Ocal, Dilek Suzuki, Ayako Suzuki, Tatsuto Mengoudi, Kyriaki Papadosifos, Nikolaos Boampong, Derrick Tyler, Nick Frost, Chris Crutch, Sebastian J. |
author_sort | Yong, Keir X. X. |
collection | PubMed |
description | INTRODUCTION: Clinical reports describe patients with Alzheimer's disease (AD) exhibiting atypical adaptive walking responses to the visual environment; however, there is limited empirical investigation of such behaviors or factors modulating their expression. We aim to evaluate effects of lighting‐based interventions and clinical presentation (visual‐ vs memory‐led) on walking function in participants with posterior cortical atrophy (PCA) and typical AD (tAD). METHODS: Participants with PCA (n = 10), tAD (n = 9), and healthy controls (n = 12) walked to visible target destinations under different lighting conditions within two pilot repeated‐measures design investigations (Experiment 1: 32 trials per participant; Experiment 2: 36 trials per participant). Participants walked to destinations with the floorpath interrupted by shadows varying in spatial extent (Experiment 1: no, medium, high shadow) or with different localized parts of the environment illuminated (Experiment 2: target, middle, or distractor illuminated). The primary study outcome for both experimental tasks was completion time; secondary kinematic outcomes were proportions of steps identified as outliers (Experiment 1) and walking path directness (Experiment 2). RESULTS: In Experiment 1, PCA participants overall demonstrated modest reductions in time taken to reach destinations when walking to destinations uninterrupted by shadows compared to high shadow conditions (7.1% reduction [95% confidence interval 2.5, 11.5; P = .003]). Experiment 2 found no evidence of differences in task performance for different localized lighting conditions in PCA participants overall. Neither experiment found evidence of differences in task performance between conditions in tAD or control participants overall. Completion time in both patient groups was longer relative to controls, and longer in PCA relative to tAD groups. DISCUSSION: Findings represent a quantitative characterization of a clinical phenomenon involving patients misperceiving shadows, implicating dementia‐related cortico‐visual impairments. Results contribute to evidence‐based design guidelines for dementia‐friendly environments. |
format | Online Article Text |
id | pubmed-7539669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75396692020-10-09 Effects of lighting variability on locomotion in posterior cortical atrophy Yong, Keir X. X. McCarthy, Ian D. Poole, Teresa Ocal, Dilek Suzuki, Ayako Suzuki, Tatsuto Mengoudi, Kyriaki Papadosifos, Nikolaos Boampong, Derrick Tyler, Nick Frost, Chris Crutch, Sebastian J. Alzheimers Dement (N Y) Research Articles INTRODUCTION: Clinical reports describe patients with Alzheimer's disease (AD) exhibiting atypical adaptive walking responses to the visual environment; however, there is limited empirical investigation of such behaviors or factors modulating their expression. We aim to evaluate effects of lighting‐based interventions and clinical presentation (visual‐ vs memory‐led) on walking function in participants with posterior cortical atrophy (PCA) and typical AD (tAD). METHODS: Participants with PCA (n = 10), tAD (n = 9), and healthy controls (n = 12) walked to visible target destinations under different lighting conditions within two pilot repeated‐measures design investigations (Experiment 1: 32 trials per participant; Experiment 2: 36 trials per participant). Participants walked to destinations with the floorpath interrupted by shadows varying in spatial extent (Experiment 1: no, medium, high shadow) or with different localized parts of the environment illuminated (Experiment 2: target, middle, or distractor illuminated). The primary study outcome for both experimental tasks was completion time; secondary kinematic outcomes were proportions of steps identified as outliers (Experiment 1) and walking path directness (Experiment 2). RESULTS: In Experiment 1, PCA participants overall demonstrated modest reductions in time taken to reach destinations when walking to destinations uninterrupted by shadows compared to high shadow conditions (7.1% reduction [95% confidence interval 2.5, 11.5; P = .003]). Experiment 2 found no evidence of differences in task performance for different localized lighting conditions in PCA participants overall. Neither experiment found evidence of differences in task performance between conditions in tAD or control participants overall. Completion time in both patient groups was longer relative to controls, and longer in PCA relative to tAD groups. DISCUSSION: Findings represent a quantitative characterization of a clinical phenomenon involving patients misperceiving shadows, implicating dementia‐related cortico‐visual impairments. Results contribute to evidence‐based design guidelines for dementia‐friendly environments. John Wiley and Sons Inc. 2020-10-07 /pmc/articles/PMC7539669/ /pubmed/33043109 http://dx.doi.org/10.1002/trc2.12077 Text en © 2020 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Yong, Keir X. X. McCarthy, Ian D. Poole, Teresa Ocal, Dilek Suzuki, Ayako Suzuki, Tatsuto Mengoudi, Kyriaki Papadosifos, Nikolaos Boampong, Derrick Tyler, Nick Frost, Chris Crutch, Sebastian J. Effects of lighting variability on locomotion in posterior cortical atrophy |
title | Effects of lighting variability on locomotion in posterior cortical atrophy |
title_full | Effects of lighting variability on locomotion in posterior cortical atrophy |
title_fullStr | Effects of lighting variability on locomotion in posterior cortical atrophy |
title_full_unstemmed | Effects of lighting variability on locomotion in posterior cortical atrophy |
title_short | Effects of lighting variability on locomotion in posterior cortical atrophy |
title_sort | effects of lighting variability on locomotion in posterior cortical atrophy |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539669/ https://www.ncbi.nlm.nih.gov/pubmed/33043109 http://dx.doi.org/10.1002/trc2.12077 |
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