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Outcomes of Hospitalized COVID-19 Patients by Risk Factors: Results from a United States Hospital Claims Database

BACKGROUND/OBJECTIVE: The primary objective was to quantify the role of the number of Centers of Disease Control and Prevention (CDC) risk factors on in-hospital mortality. The secondary objective was to assess the associated hospital length of stay (LOS), intensive care unit (ICU) bed utilization,...

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Autores principales: Mallow, Peter J., Belk, Kathy W., Topmiller, Michael, Hooker, Edmond A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Columbia Data Analytics, LLC 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539762/
https://www.ncbi.nlm.nih.gov/pubmed/33043063
http://dx.doi.org/10.36469/jheor.2020.17331
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author Mallow, Peter J.
Belk, Kathy W.
Topmiller, Michael
Hooker, Edmond A.
author_facet Mallow, Peter J.
Belk, Kathy W.
Topmiller, Michael
Hooker, Edmond A.
author_sort Mallow, Peter J.
collection PubMed
description BACKGROUND/OBJECTIVE: The primary objective was to quantify the role of the number of Centers of Disease Control and Prevention (CDC) risk factors on in-hospital mortality. The secondary objective was to assess the associated hospital length of stay (LOS), intensive care unit (ICU) bed utilization, and ICU LOS with the number of CDC risk factors. METHODS: A retrospective cohort study consisting of all hospitalizations with a confirmed COVID-19 diagnosis discharged between March 15, 2020 and April 30, 2020 was conducted. Data was obtained from 276 acute care hospitals across the United States. Cohorts were identified based upon the number of the CDC COVID-19 risk factors. Multivariable regression modeling was performed to assess outcomes and utilization. The odds ratio (OR) and incidence rate ratio (IRR) were reported. RESULTS: Compared with patients with no CDC risk factors, patients with risk factors were significantly more likely to die during the hospitalization: One risk factor (OR 2.08, 95% CI, 1.60–2.70; P < 0.001), two risk factors (OR 2.63, 95% CI, 2.00–3.47; P < 0.001), and three or more risk factors (OR 3.49, 95% CI, 2.53–4.80; P < 0.001). The presence of CDC risk factors was associated with increased ICU utilization, longer ICU LOS, and longer hospital LOS compared to those with no risk factors. Patients with hypertension (OR 0.77, 95% CI, 0.70–0.86; P < 0.001) and those administered statins were less likely to die (OR 0.54, 95% CI, 0.49–0.60; P < 0.001). CONCLUSIONS: Quantifying the role of CDC risk factors upon admission may improve risk stratification and identification of patients who may require closer monitoring and more intensive treatment.
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spelling pubmed-75397622020-10-08 Outcomes of Hospitalized COVID-19 Patients by Risk Factors: Results from a United States Hospital Claims Database Mallow, Peter J. Belk, Kathy W. Topmiller, Michael Hooker, Edmond A. J Health Econ Outcomes Res Infectious Diseases BACKGROUND/OBJECTIVE: The primary objective was to quantify the role of the number of Centers of Disease Control and Prevention (CDC) risk factors on in-hospital mortality. The secondary objective was to assess the associated hospital length of stay (LOS), intensive care unit (ICU) bed utilization, and ICU LOS with the number of CDC risk factors. METHODS: A retrospective cohort study consisting of all hospitalizations with a confirmed COVID-19 diagnosis discharged between March 15, 2020 and April 30, 2020 was conducted. Data was obtained from 276 acute care hospitals across the United States. Cohorts were identified based upon the number of the CDC COVID-19 risk factors. Multivariable regression modeling was performed to assess outcomes and utilization. The odds ratio (OR) and incidence rate ratio (IRR) were reported. RESULTS: Compared with patients with no CDC risk factors, patients with risk factors were significantly more likely to die during the hospitalization: One risk factor (OR 2.08, 95% CI, 1.60–2.70; P < 0.001), two risk factors (OR 2.63, 95% CI, 2.00–3.47; P < 0.001), and three or more risk factors (OR 3.49, 95% CI, 2.53–4.80; P < 0.001). The presence of CDC risk factors was associated with increased ICU utilization, longer ICU LOS, and longer hospital LOS compared to those with no risk factors. Patients with hypertension (OR 0.77, 95% CI, 0.70–0.86; P < 0.001) and those administered statins were less likely to die (OR 0.54, 95% CI, 0.49–0.60; P < 0.001). CONCLUSIONS: Quantifying the role of CDC risk factors upon admission may improve risk stratification and identification of patients who may require closer monitoring and more intensive treatment. Columbia Data Analytics, LLC 2020-09-29 /pmc/articles/PMC7539762/ /pubmed/33043063 http://dx.doi.org/10.36469/jheor.2020.17331 Text en This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CCBY-4.0). View this license’s legal deed at http://creativecommons.org/licenses/by/4.0 and legal code at http://creativecommons.org/licenses/by/4.0/legalcode for more information.
spellingShingle Infectious Diseases
Mallow, Peter J.
Belk, Kathy W.
Topmiller, Michael
Hooker, Edmond A.
Outcomes of Hospitalized COVID-19 Patients by Risk Factors: Results from a United States Hospital Claims Database
title Outcomes of Hospitalized COVID-19 Patients by Risk Factors: Results from a United States Hospital Claims Database
title_full Outcomes of Hospitalized COVID-19 Patients by Risk Factors: Results from a United States Hospital Claims Database
title_fullStr Outcomes of Hospitalized COVID-19 Patients by Risk Factors: Results from a United States Hospital Claims Database
title_full_unstemmed Outcomes of Hospitalized COVID-19 Patients by Risk Factors: Results from a United States Hospital Claims Database
title_short Outcomes of Hospitalized COVID-19 Patients by Risk Factors: Results from a United States Hospital Claims Database
title_sort outcomes of hospitalized covid-19 patients by risk factors: results from a united states hospital claims database
topic Infectious Diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539762/
https://www.ncbi.nlm.nih.gov/pubmed/33043063
http://dx.doi.org/10.36469/jheor.2020.17331
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