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Asthma and COPD Are Not Risk Factors for ICU Stay and Death in Case of SARS-CoV2 Infection

BACKGROUND: Asthmatics and patients with chronic obstructive pulmonary disease (COPD) have more severe outcomes with viral infections than people without obstructive disease. OBJECTIVE: To evaluate if obstructive diseases are risk factors for intensive care unit (ICU) stay and death due to coronavir...

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Autores principales: Calmes, Doriane, Graff, Sophie, Maes, Nathalie, Frix, Anne-Noëlle, Thys, Marie, Bonhomme, Olivier, Berg, Julien, Debruche, Mathieu, Gester, Fanny, Henket, Monique, Paulus, Virginie, Duysinx, Bernard, Heinen, Vincent, Dang, Delphine Nguyen, Paulus, Astrid, Quaedvlieg, Valérie, Vaillant, Frederique, Van Cauwenberge, Hélène, Malaise, Michel, Gilbert, Alisson, Ghuysen, Alexandre, Gillet, Pierre, Moutschen, Michel, Misset, Benoit, Sibille, Anne, Guiot, Julien, Corhay, Jean-Louis, Louis, Renaud, Schleich, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539890/
https://www.ncbi.nlm.nih.gov/pubmed/33038592
http://dx.doi.org/10.1016/j.jaip.2020.09.044
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author Calmes, Doriane
Graff, Sophie
Maes, Nathalie
Frix, Anne-Noëlle
Thys, Marie
Bonhomme, Olivier
Berg, Julien
Debruche, Mathieu
Gester, Fanny
Henket, Monique
Paulus, Virginie
Duysinx, Bernard
Heinen, Vincent
Dang, Delphine Nguyen
Paulus, Astrid
Quaedvlieg, Valérie
Vaillant, Frederique
Van Cauwenberge, Hélène
Malaise, Michel
Gilbert, Alisson
Ghuysen, Alexandre
Gillet, Pierre
Moutschen, Michel
Misset, Benoit
Sibille, Anne
Guiot, Julien
Corhay, Jean-Louis
Louis, Renaud
Schleich, Florence
author_facet Calmes, Doriane
Graff, Sophie
Maes, Nathalie
Frix, Anne-Noëlle
Thys, Marie
Bonhomme, Olivier
Berg, Julien
Debruche, Mathieu
Gester, Fanny
Henket, Monique
Paulus, Virginie
Duysinx, Bernard
Heinen, Vincent
Dang, Delphine Nguyen
Paulus, Astrid
Quaedvlieg, Valérie
Vaillant, Frederique
Van Cauwenberge, Hélène
Malaise, Michel
Gilbert, Alisson
Ghuysen, Alexandre
Gillet, Pierre
Moutschen, Michel
Misset, Benoit
Sibille, Anne
Guiot, Julien
Corhay, Jean-Louis
Louis, Renaud
Schleich, Florence
author_sort Calmes, Doriane
collection PubMed
description BACKGROUND: Asthmatics and patients with chronic obstructive pulmonary disease (COPD) have more severe outcomes with viral infections than people without obstructive disease. OBJECTIVE: To evaluate if obstructive diseases are risk factors for intensive care unit (ICU) stay and death due to coronavirus disease 2019 (COVID19). METHODS: We collected data from the electronic medical record from 596 adult patients hospitalized in University Hospital of Liege between March 18 and April 17, 2020, for severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection. We classified patients into 3 groups according to the underlying respiratory disease, present before the COVID19 pandemic. RESULTS: Among patients requiring hospitalization for COVID19, asthma and COPD accounted for 9.6% and 7.7%, respectively. The proportions of asthmatics, patients with COPD, and patients without obstructive airway disease hospitalized in the ICU were 17.5%, 19.6%, and 14%, respectively. One-third of patients with COPD died during hospitalization, whereas only 7.0% of asthmatics and 13.6% of patients without airway obstruction died due to SARS-CoV2. The multivariate analysis showed that asthma, COPD, inhaled corticosteroid treatment, and oral corticosteroid treatment were not independent risk factors for ICU admission or death. Male gender (odds ratio [OR]: 1.9; 95% confidence interval [CI]: 1.1-3.2) and obesity (OR: 8.5; 95% CI: 5.1-14.1) were predictors of ICU admission, whereas male gender (OR 1.9; 95% CI: 1.1-3.2), older age (OR: 1.9; 95% CI: 1.6-2.3), cardiopathy (OR: 1.8; 95% CI: 1.1-3.1), and immunosuppressive diseases (OR: 3.6; 95% CI: 1.5-8.4) were independent predictors of death. CONCLUSION: Asthma and COPD are not risk factors for ICU admission and death related to SARS-CoV2 infection.
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spelling pubmed-75398902020-10-08 Asthma and COPD Are Not Risk Factors for ICU Stay and Death in Case of SARS-CoV2 Infection Calmes, Doriane Graff, Sophie Maes, Nathalie Frix, Anne-Noëlle Thys, Marie Bonhomme, Olivier Berg, Julien Debruche, Mathieu Gester, Fanny Henket, Monique Paulus, Virginie Duysinx, Bernard Heinen, Vincent Dang, Delphine Nguyen Paulus, Astrid Quaedvlieg, Valérie Vaillant, Frederique Van Cauwenberge, Hélène Malaise, Michel Gilbert, Alisson Ghuysen, Alexandre Gillet, Pierre Moutschen, Michel Misset, Benoit Sibille, Anne Guiot, Julien Corhay, Jean-Louis Louis, Renaud Schleich, Florence J Allergy Clin Immunol Pract Original Article BACKGROUND: Asthmatics and patients with chronic obstructive pulmonary disease (COPD) have more severe outcomes with viral infections than people without obstructive disease. OBJECTIVE: To evaluate if obstructive diseases are risk factors for intensive care unit (ICU) stay and death due to coronavirus disease 2019 (COVID19). METHODS: We collected data from the electronic medical record from 596 adult patients hospitalized in University Hospital of Liege between March 18 and April 17, 2020, for severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection. We classified patients into 3 groups according to the underlying respiratory disease, present before the COVID19 pandemic. RESULTS: Among patients requiring hospitalization for COVID19, asthma and COPD accounted for 9.6% and 7.7%, respectively. The proportions of asthmatics, patients with COPD, and patients without obstructive airway disease hospitalized in the ICU were 17.5%, 19.6%, and 14%, respectively. One-third of patients with COPD died during hospitalization, whereas only 7.0% of asthmatics and 13.6% of patients without airway obstruction died due to SARS-CoV2. The multivariate analysis showed that asthma, COPD, inhaled corticosteroid treatment, and oral corticosteroid treatment were not independent risk factors for ICU admission or death. Male gender (odds ratio [OR]: 1.9; 95% confidence interval [CI]: 1.1-3.2) and obesity (OR: 8.5; 95% CI: 5.1-14.1) were predictors of ICU admission, whereas male gender (OR 1.9; 95% CI: 1.1-3.2), older age (OR: 1.9; 95% CI: 1.6-2.3), cardiopathy (OR: 1.8; 95% CI: 1.1-3.1), and immunosuppressive diseases (OR: 3.6; 95% CI: 1.5-8.4) were independent predictors of death. CONCLUSION: Asthma and COPD are not risk factors for ICU admission and death related to SARS-CoV2 infection. The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. 2021-01 2020-10-07 /pmc/articles/PMC7539890/ /pubmed/33038592 http://dx.doi.org/10.1016/j.jaip.2020.09.044 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Calmes, Doriane
Graff, Sophie
Maes, Nathalie
Frix, Anne-Noëlle
Thys, Marie
Bonhomme, Olivier
Berg, Julien
Debruche, Mathieu
Gester, Fanny
Henket, Monique
Paulus, Virginie
Duysinx, Bernard
Heinen, Vincent
Dang, Delphine Nguyen
Paulus, Astrid
Quaedvlieg, Valérie
Vaillant, Frederique
Van Cauwenberge, Hélène
Malaise, Michel
Gilbert, Alisson
Ghuysen, Alexandre
Gillet, Pierre
Moutschen, Michel
Misset, Benoit
Sibille, Anne
Guiot, Julien
Corhay, Jean-Louis
Louis, Renaud
Schleich, Florence
Asthma and COPD Are Not Risk Factors for ICU Stay and Death in Case of SARS-CoV2 Infection
title Asthma and COPD Are Not Risk Factors for ICU Stay and Death in Case of SARS-CoV2 Infection
title_full Asthma and COPD Are Not Risk Factors for ICU Stay and Death in Case of SARS-CoV2 Infection
title_fullStr Asthma and COPD Are Not Risk Factors for ICU Stay and Death in Case of SARS-CoV2 Infection
title_full_unstemmed Asthma and COPD Are Not Risk Factors for ICU Stay and Death in Case of SARS-CoV2 Infection
title_short Asthma and COPD Are Not Risk Factors for ICU Stay and Death in Case of SARS-CoV2 Infection
title_sort asthma and copd are not risk factors for icu stay and death in case of sars-cov2 infection
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539890/
https://www.ncbi.nlm.nih.gov/pubmed/33038592
http://dx.doi.org/10.1016/j.jaip.2020.09.044
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