The sodium channel Na(V)1.5 impacts on early murine embryonic cardiac development, structure and function in a non‐electrogenic manner

AIM: The voltage‐gated sodium channel Na(V)1.5, encoded by SCN5A, is essential for cardiac excitability and ensures proper electrical conduction. Early embryonic death has been observed in several murine models carrying homozygous Scn5amutations. We investigated when sodium current (I(Na)) becomes f...

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Detalles Bibliográficos
Autores principales: Marchal, Gerard A., Verkerk, Arie O., Mohan, Rajiv A., Wolswinkel, Rianne, Boukens, Bastiaan J. D., Remme, Carol Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Cardiovascular Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539970/
https://www.ncbi.nlm.nih.gov/pubmed/32386467
http://dx.doi.org/10.1111/apha.13493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539970/
https://www.ncbi.nlm.nih.gov/pubmed/32386467
http://dx.doi.org/10.1111/apha.13493

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