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Total Synthesis of (+)‐Cornexistin

Herein, we describe the first total synthesis of (+)‐cornexistin as well as its 8‐epi‐isomer starting from malic acid. The robust and scalable route features a Nozaki–Hiyama–Kishi reaction, an auxiliary‐controlled syn‐Evans‐aldol reaction, and a highly efficient intramolecular alkylation to form the...

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Detalles Bibliográficos
Autores principales:	Steinborn, Christian, Wildermuth, Raphael E., Barber, David M., Magauer, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540023/ https://www.ncbi.nlm.nih.gov/pubmed/32558114 http://dx.doi.org/10.1002/anie.202008158

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