The Role of Cardiac Macrophage and Cytokines on Ventricular Arrhythmias

In the heart, cardiac macrophages have widespread biological functions, including roles in antigen presentation, phagocytosis, and immunoregulation, through the formation of diverse cytokines and growth factors; thus, these cells play an active role in tissue repair after heart injury. Recent clinic...

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Autores principales: Chen, Mingxian, Li, Xuping, Wang, Songyun, Yu, Lilei, Tang, Jianjun, Zhou, Shenghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540080/
https://www.ncbi.nlm.nih.gov/pubmed/33071805
http://dx.doi.org/10.3389/fphys.2020.01113
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author Chen, Mingxian
Li, Xuping
Wang, Songyun
Yu, Lilei
Tang, Jianjun
Zhou, Shenghua
author_facet Chen, Mingxian
Li, Xuping
Wang, Songyun
Yu, Lilei
Tang, Jianjun
Zhou, Shenghua
author_sort Chen, Mingxian
collection PubMed
description In the heart, cardiac macrophages have widespread biological functions, including roles in antigen presentation, phagocytosis, and immunoregulation, through the formation of diverse cytokines and growth factors; thus, these cells play an active role in tissue repair after heart injury. Recent clinical studies have indicated that macrophages or elevated inflammatory cytokines secreted by macrophages are closely related to ventricular arrhythmias (VAs). This review describes the role of macrophages and macrophage-secreted inflammatory cytokines in ventricular arrhythmogenesis.
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spelling pubmed-75400802020-10-15 The Role of Cardiac Macrophage and Cytokines on Ventricular Arrhythmias Chen, Mingxian Li, Xuping Wang, Songyun Yu, Lilei Tang, Jianjun Zhou, Shenghua Front Physiol Physiology In the heart, cardiac macrophages have widespread biological functions, including roles in antigen presentation, phagocytosis, and immunoregulation, through the formation of diverse cytokines and growth factors; thus, these cells play an active role in tissue repair after heart injury. Recent clinical studies have indicated that macrophages or elevated inflammatory cytokines secreted by macrophages are closely related to ventricular arrhythmias (VAs). This review describes the role of macrophages and macrophage-secreted inflammatory cytokines in ventricular arrhythmogenesis. Frontiers Media S.A. 2020-09-23 /pmc/articles/PMC7540080/ /pubmed/33071805 http://dx.doi.org/10.3389/fphys.2020.01113 Text en Copyright © 2020 Chen, Li, Wang, Yu, Tang and Zhou. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Chen, Mingxian
Li, Xuping
Wang, Songyun
Yu, Lilei
Tang, Jianjun
Zhou, Shenghua
The Role of Cardiac Macrophage and Cytokines on Ventricular Arrhythmias
title The Role of Cardiac Macrophage and Cytokines on Ventricular Arrhythmias
title_full The Role of Cardiac Macrophage and Cytokines on Ventricular Arrhythmias
title_fullStr The Role of Cardiac Macrophage and Cytokines on Ventricular Arrhythmias
title_full_unstemmed The Role of Cardiac Macrophage and Cytokines on Ventricular Arrhythmias
title_short The Role of Cardiac Macrophage and Cytokines on Ventricular Arrhythmias
title_sort role of cardiac macrophage and cytokines on ventricular arrhythmias
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540080/
https://www.ncbi.nlm.nih.gov/pubmed/33071805
http://dx.doi.org/10.3389/fphys.2020.01113
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