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The additional contribution of second nasopharyngeal PCR to COVID-19 diagnosis in patients with negative initial test

OBJECTIVE: The World Health Organization (WHO) recommends performing a second test in patients with a high suspicion of novel coronavirus disease (COVID-19) whose first PCR test is negative. However, the additional contribution of the second PCR test to the diagnosis is unknown. PATIENTS AND METHODS...

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Autores principales: Kayaaslan, B., Kaya Kalem, A., Eser, F., Hasanoglu, I., Guner, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Masson SAS. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540190/
https://www.ncbi.nlm.nih.gov/pubmed/33038445
http://dx.doi.org/10.1016/j.medmal.2020.10.003
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author Kayaaslan, B.
Kaya Kalem, A.
Eser, F.
Hasanoglu, I.
Guner, R.
author_facet Kayaaslan, B.
Kaya Kalem, A.
Eser, F.
Hasanoglu, I.
Guner, R.
author_sort Kayaaslan, B.
collection PubMed
description OBJECTIVE: The World Health Organization (WHO) recommends performing a second test in patients with a high suspicion of novel coronavirus disease (COVID-19) whose first PCR test is negative. However, the additional contribution of the second PCR test to the diagnosis is unknown. PATIENTS AND METHODS: In this study, we aimed to investigate the contribution of second SARS-CoV-2 PCR to diagnosis in patients with a suspicion of COVID-19 whose initial test was negative. RESULTS: A total of 1449 patients were hospitalized in infectious disease clinics with the suspicion of COVID-19 infection during the study period. We performed the second PCR test (697 nasopharyngeal sample, 5 tracheal aspirate) in 702/766 (91.6%) patients whose first tests were negative and only 6.6% (46) of them were positive. CONCLUSIONS: The strategy of using the second nasopharyngeal PCR test to confirm or exclude the diagnosis seems to cause the loss of labor and time, and is costly, because its additional contribution to the first test is very low.
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spelling pubmed-75401902020-10-08 The additional contribution of second nasopharyngeal PCR to COVID-19 diagnosis in patients with negative initial test Kayaaslan, B. Kaya Kalem, A. Eser, F. Hasanoglu, I. Guner, R. Infect Dis Now Short Communication OBJECTIVE: The World Health Organization (WHO) recommends performing a second test in patients with a high suspicion of novel coronavirus disease (COVID-19) whose first PCR test is negative. However, the additional contribution of the second PCR test to the diagnosis is unknown. PATIENTS AND METHODS: In this study, we aimed to investigate the contribution of second SARS-CoV-2 PCR to diagnosis in patients with a suspicion of COVID-19 whose initial test was negative. RESULTS: A total of 1449 patients were hospitalized in infectious disease clinics with the suspicion of COVID-19 infection during the study period. We performed the second PCR test (697 nasopharyngeal sample, 5 tracheal aspirate) in 702/766 (91.6%) patients whose first tests were negative and only 6.6% (46) of them were positive. CONCLUSIONS: The strategy of using the second nasopharyngeal PCR test to confirm or exclude the diagnosis seems to cause the loss of labor and time, and is costly, because its additional contribution to the first test is very low. Published by Elsevier Masson SAS. 2021-03 2021-01-18 /pmc/articles/PMC7540190/ /pubmed/33038445 http://dx.doi.org/10.1016/j.medmal.2020.10.003 Text en © 2020 Published by Elsevier Masson SAS. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Kayaaslan, B.
Kaya Kalem, A.
Eser, F.
Hasanoglu, I.
Guner, R.
The additional contribution of second nasopharyngeal PCR to COVID-19 diagnosis in patients with negative initial test
title The additional contribution of second nasopharyngeal PCR to COVID-19 diagnosis in patients with negative initial test
title_full The additional contribution of second nasopharyngeal PCR to COVID-19 diagnosis in patients with negative initial test
title_fullStr The additional contribution of second nasopharyngeal PCR to COVID-19 diagnosis in patients with negative initial test
title_full_unstemmed The additional contribution of second nasopharyngeal PCR to COVID-19 diagnosis in patients with negative initial test
title_short The additional contribution of second nasopharyngeal PCR to COVID-19 diagnosis in patients with negative initial test
title_sort additional contribution of second nasopharyngeal pcr to covid-19 diagnosis in patients with negative initial test
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540190/
https://www.ncbi.nlm.nih.gov/pubmed/33038445
http://dx.doi.org/10.1016/j.medmal.2020.10.003
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