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Low concordance of short‐term and long‐term selection responses in experimental Drosophila populations

Experimental evolution is becoming a popular approach to study the genomic selection response of evolving populations. Computer simulation studies suggest that the accuracy of the signature increases with the duration of the experiment. Since some assumptions of the computer simulations may be viola...

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Autores principales: Langmüller, Anna Maria, Schlötterer, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540288/
https://www.ncbi.nlm.nih.gov/pubmed/32762052
http://dx.doi.org/10.1111/mec.15579
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author Langmüller, Anna Maria
Schlötterer, Christian
author_facet Langmüller, Anna Maria
Schlötterer, Christian
author_sort Langmüller, Anna Maria
collection PubMed
description Experimental evolution is becoming a popular approach to study the genomic selection response of evolving populations. Computer simulation studies suggest that the accuracy of the signature increases with the duration of the experiment. Since some assumptions of the computer simulations may be violated, it is important to scrutinize the influence of the experimental duration with real data. Here, we use a highly replicated Evolve and Resequence study in Drosophila simulans to compare the selection targets inferred at different time points. At each time point, approximately the same number of SNPs deviates from neutral expectations, but only 10% of the selected haplotype blocks identified from the full data set can be detected after 20 generations. Those haplotype blocks that emerge already after 20 generations differ from the others by being strongly selected at the beginning of the experiment and display a more parallel selection response. Consistent with previous computer simulations, our results demonstrate that only Evolve and Resequence experiments with a sufficient number of generations can characterize complex adaptive architectures.
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spelling pubmed-75402882020-10-09 Low concordance of short‐term and long‐term selection responses in experimental Drosophila populations Langmüller, Anna Maria Schlötterer, Christian Mol Ecol ORIGINAL ARTICLES Experimental evolution is becoming a popular approach to study the genomic selection response of evolving populations. Computer simulation studies suggest that the accuracy of the signature increases with the duration of the experiment. Since some assumptions of the computer simulations may be violated, it is important to scrutinize the influence of the experimental duration with real data. Here, we use a highly replicated Evolve and Resequence study in Drosophila simulans to compare the selection targets inferred at different time points. At each time point, approximately the same number of SNPs deviates from neutral expectations, but only 10% of the selected haplotype blocks identified from the full data set can be detected after 20 generations. Those haplotype blocks that emerge already after 20 generations differ from the others by being strongly selected at the beginning of the experiment and display a more parallel selection response. Consistent with previous computer simulations, our results demonstrate that only Evolve and Resequence experiments with a sufficient number of generations can characterize complex adaptive architectures. John Wiley and Sons Inc. 2020-08-26 2020-09 /pmc/articles/PMC7540288/ /pubmed/32762052 http://dx.doi.org/10.1111/mec.15579 Text en © 2020 The Authors. Molecular Ecology published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle ORIGINAL ARTICLES
Langmüller, Anna Maria
Schlötterer, Christian
Low concordance of short‐term and long‐term selection responses in experimental Drosophila populations
title Low concordance of short‐term and long‐term selection responses in experimental Drosophila populations
title_full Low concordance of short‐term and long‐term selection responses in experimental Drosophila populations
title_fullStr Low concordance of short‐term and long‐term selection responses in experimental Drosophila populations
title_full_unstemmed Low concordance of short‐term and long‐term selection responses in experimental Drosophila populations
title_short Low concordance of short‐term and long‐term selection responses in experimental Drosophila populations
title_sort low concordance of short‐term and long‐term selection responses in experimental drosophila populations
topic ORIGINAL ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540288/
https://www.ncbi.nlm.nih.gov/pubmed/32762052
http://dx.doi.org/10.1111/mec.15579
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