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Generation of pralatrexate resistant T‐cell lymphoma lines reveals two patterns of acquired drug resistance that is overcome with epigenetic modifiers
While pralatrexate (PDX) has been successfully developed for the treatment of T‐cell lymphoma, the mechanistic basis for its T‐cell selectivity and acquired resistance remains elusive. In an effort to potentially identify synergistic combinations that might circumnavigate or delay acquired PDX resis...
Autores principales: | Scotto, Luigi, Kinahan, Cristina, Casadei, Beatrice, Mangone, Michael, Douglass, Eugene, Murty, Vundavalli V., Marchi, Enrica, Ma, Helen, George, Changchun, Montanari, Francesca, Califano, Andrea, O'Connor, Owen A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540375/ https://www.ncbi.nlm.nih.gov/pubmed/32614991 http://dx.doi.org/10.1002/gcc.22884 |
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