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Obligatory metabolomic profiling of gene‐edited crops is risk disproportionate
It has been argued that the application of metabolomics to gene‐edited crops would present value in three areas: (i) the detection of gene‐edited crops; (ii) the characterization of unexpected changes that might affect safety; and (iii) building on the track record of rigorous government regulation...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540486/ https://www.ncbi.nlm.nih.gov/pubmed/32593232 http://dx.doi.org/10.1111/tpj.14896 |
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author | Fedorova, Maria Herman, Rod A. |
author_facet | Fedorova, Maria Herman, Rod A. |
author_sort | Fedorova, Maria |
collection | PubMed |
description | It has been argued that the application of metabolomics to gene‐edited crops would present value in three areas: (i) the detection of gene‐edited crops; (ii) the characterization of unexpected changes that might affect safety; and (iii) building on the track record of rigorous government regulation in supporting consumer acceptance of genetically modified organisms (GMOs). Here, we offer a different perspective, relative to each of these areas: (i) metabolomics is unable to differentiate whether a mutation has resulted from gene editing or from traditional breeding techniques; (ii) it is risk‐disproportionate to apply metabolomics for regulatory purposes to search for possible compositional differences within crops developed using the least likely technique to generate unexpected compositional changes; and (iii) onerous regulations for genetically engineered crops have only contributed to unwarranted public fears, and repeating this approach for gene‐edited crops is unlikely to result in a different outcome. It is also suggested that article proposing the utility of specific analytical techniques to support risk assessment would benefit from the input of scientists with subject matter expertise in risk assessment. |
format | Online Article Text |
id | pubmed-7540486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75404862020-10-09 Obligatory metabolomic profiling of gene‐edited crops is risk disproportionate Fedorova, Maria Herman, Rod A. Plant J Perspective It has been argued that the application of metabolomics to gene‐edited crops would present value in three areas: (i) the detection of gene‐edited crops; (ii) the characterization of unexpected changes that might affect safety; and (iii) building on the track record of rigorous government regulation in supporting consumer acceptance of genetically modified organisms (GMOs). Here, we offer a different perspective, relative to each of these areas: (i) metabolomics is unable to differentiate whether a mutation has resulted from gene editing or from traditional breeding techniques; (ii) it is risk‐disproportionate to apply metabolomics for regulatory purposes to search for possible compositional differences within crops developed using the least likely technique to generate unexpected compositional changes; and (iii) onerous regulations for genetically engineered crops have only contributed to unwarranted public fears, and repeating this approach for gene‐edited crops is unlikely to result in a different outcome. It is also suggested that article proposing the utility of specific analytical techniques to support risk assessment would benefit from the input of scientists with subject matter expertise in risk assessment. John Wiley and Sons Inc. 2020-07-20 2020-09 /pmc/articles/PMC7540486/ /pubmed/32593232 http://dx.doi.org/10.1111/tpj.14896 Text en © 2020 Corteva Agriscience. The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Perspective Fedorova, Maria Herman, Rod A. Obligatory metabolomic profiling of gene‐edited crops is risk disproportionate |
title | Obligatory metabolomic profiling of gene‐edited crops is risk disproportionate |
title_full | Obligatory metabolomic profiling of gene‐edited crops is risk disproportionate |
title_fullStr | Obligatory metabolomic profiling of gene‐edited crops is risk disproportionate |
title_full_unstemmed | Obligatory metabolomic profiling of gene‐edited crops is risk disproportionate |
title_short | Obligatory metabolomic profiling of gene‐edited crops is risk disproportionate |
title_sort | obligatory metabolomic profiling of gene‐edited crops is risk disproportionate |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540486/ https://www.ncbi.nlm.nih.gov/pubmed/32593232 http://dx.doi.org/10.1111/tpj.14896 |
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