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Assessment of romiplostim immunogenicity in adult patients in clinical trials and in a global postmarketing registry

Antibodies to first‐generation recombinant thrombopoietin (TPO) neutralized endogenous TPO and caused thrombocytopenia in some healthy subjects and chemotherapy patients. The second‐generation TPO receptor agonist romiplostim, having no sequence homology to TPO, was developed to avoid immunogenicity...

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Detalles Bibliográficos
Autores principales:	Mytych, Daniel T., Park, Joseph K., Kim, June, Barger, Troy E., Boshier, Andy, Jawa, Vibha, Kuter, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Platelets Haemostasis and Thrombosis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540503/ https://www.ncbi.nlm.nih.gov/pubmed/32311075 http://dx.doi.org/10.1111/bjh.16658

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