Depletion of cyclic‐GMP levels and inhibition of cGMP‐dependent protein kinase activate p21(Cip1)/p27(Kip1) pathways and lead to renal fibrosis and dysfunction

Cell‐cycle regulatory proteins (p21(Cip1)/p27(Kip1)) inhibit cyclin and cyclin‐dependent kinase (CDK) complex that promotes fibrosis and hypertrophy. The present study examined the role of CDK blockers, p21(Cip1)/p27(Kip1) in the progression of renal fibrosis and dysfunction using Npr1 (encoding gua...

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Detalles Bibliográficos
Autores principales: Das, Subhankar, Neelamegam, Kandasamy, Peters, Whitney N., Periyasamy, Ramu, Pandey, Kailash N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540536/
https://www.ncbi.nlm.nih.gov/pubmed/32686172
http://dx.doi.org/10.1096/fj.202000754R

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