Cargando…

Systematic Evaluation of Imine‐Reducing Enzymes: Common Principles in Imine Reductases, β‐Hydroxy Acid Dehydrogenases, and Short‐Chain Dehydrogenases/ Reductases

The enzymatic, asymmetric reduction of imines is catalyzed by imine reductases (IREDs), members of the short‐chain dehydrogenase/reductase (SDR) family, and β‐hydroxy acid dehydrogenase (βHAD) variants. Systematic evaluation of the structures and substrate‐binding sites of the three enzyme families...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stockinger, Peter, Roth, Sebastian, Müller, Michael, Pleiss, Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540600/ https://www.ncbi.nlm.nih.gov/pubmed/32311225 http://dx.doi.org/10.1002/cbic.202000213

Ejemplares similares

Crossing the Border: From Keto‐ to Imine Reduction in Short‐Chain Dehydrogenases/Reductases
por: Roth, Sebastian, et al.
Publicado: (2020)

Inverting the Stereoselectivity of an NADH‐Dependent Imine‐Reductase Variant
por: Stockinger, Peter, et al.
Publicado: (2021)

Engineering of Thermostable β‐Hydroxyacid Dehydrogenase for the Asymmetric Reduction of Imines
por: Stockinger, Peter, et al.
Publicado: (2020)

An (R)‐Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines
por: Hussain, Shahed, et al.
Publicado: (2015)

Artificial imine reductases: developments and future directions
por: Booth, Rosalind L., et al.
Publicado: (2020)

The Discovery of Imine Reductases and their Utilisation for the Synthesis of Tetrahydroisoquinolines
por: Cárdenas‐Fernández, Max, et al.
Publicado: (2023)

Sequence‐Based In‐silico Discovery, Characterisation, and Biocatalytic Application of a Set of Imine Reductases
por: Velikogne, Stefan, et al.
Publicado: (2018)

Reductive aminations by imine reductases: from milligrams to tons
por: Gilio, Amelia K., et al.
Publicado: (2022)

Enantiocomplementary Yarrowia lipolytica Oxidoreductases: Alcohol Dehydrogenase 2 and Short Chain Dehydrogenase/Reductase
por: Napora-Wijata, Kamila, et al.
Publicado: (2013)

Structural Characterization of an S-enantioselective Imine Reductase from Mycobacterium Smegmatis
por: Meyer, Timo, et al.
Publicado: (2020)

Biosynthesis of plant tetrahydroisoquinoline alkaloids through an imine reductase route
por: Yang, Lu, et al.
Publicado: (2019)

Imine Reductase Based All-Enzyme Hydrogel with Intrinsic Cofactor Regeneration for Flow Biocatalysis
por: Bitterwolf, Patrick, et al.
Publicado: (2019)

Characterization of imine reductases in reductive amination for the exploration of structure-activity relationships
por: Montgomery, Sarah L., et al.
Publicado: (2020)

Computational Study of Mechanism and Enantioselectivity of Imine Reductase from Amycolatopsis orientalis
por: Prejanò, Mario, et al.
Publicado: (2021)

Structure-Based Design of Small Imine Reductase Panels for Target Substrates
por: Yu, Yuqi, et al.
Publicado: (2023)

Structure of the imine reductase from Ajellomyces dermatitidis in three crystal forms
por: Sharma, Mahima, et al.
Publicado: (2023)

Multiple short‐chain dehydrogenases/reductases are regulated in pathological cardiac hypertrophy
por: Roussel, Elise, et al.
Publicado: (2018)

The characterization of a short chain dehydrogenase/reductase (SDRx) in Comamonas testosteroni
por: Liu, Chuanzhi, et al.
Publicado: (2020)

Gene Structure Evolution of the Short-Chain Dehydrogenase/Reductase (SDR) Family
por: Gabrielli, Franco, et al.
Publicado: (2022)

Bioinformatic analysis of short-chain dehydrogenase/reductase proteins in plant peroxisomes
por: Zhang, Yuchan, et al.
Publicado: (2023)

Actinomycetes-derived imine reductases with a preference towards bulky amine substrates
por: Zhang, Jun, et al.
Publicado: (2022)

Medium- and short-chain dehydrogenase/reductase gene and protein families: The MDR superfamily
por: Persson, B., et al.
Publicado: (2008)

Dimerization and enzymatic activity of fungal 17β-hydroxysteroid dehydrogenase from the short-chain dehydrogenase/reductase superfamily
por: Kristan, Katja, et al.
Publicado: (2005)

A Reductive Aminase Switches to Imine Reductase Mode for a Bulky Amine Substrate
por: Gilio, Amelia K., et al.
Publicado: (2023)

Structure-guided semi-rational design of an imine reductase for enantio-complementary synthesis of pyrrolidinamine
por: Zhang, Jun, et al.
Publicado: (2023)

Delineating Substrate Diversity of Disparate Short-Chain Dehydrogenase Reductase from Debaryomyces hansenii
por: Ghatak, Arindam, et al.
Publicado: (2017)

Identification, Expression and Evolution of Short-Chain Dehydrogenases/Reductases in Nile Tilapia (Oreochromis niloticus)
por: Zhang, Shuai, et al.
Publicado: (2021)

Crystal structure of a putative short-chain dehydrogenase/reductase from Paraburkholderia xenovorans
por: Davidson, Jaysón, et al.
Publicado: (2022)

Cationic Aluminium Complexes as Catalysts for Imine Hydrogenation
por: Friedrich, Alexander, et al.
Publicado: (2021)

Predicting Protein Function from Structure—The Roles of Short-chain Dehydrogenase/Reductase Enzymes in Bordetella O-antigen Biosynthesis
por: King, Jerry D., et al.
Publicado: (2007)

Pinpointing a Mechanistic Switch Between Ketoreduction and “Ene” Reduction in Short‐Chain Dehydrogenases/Reductases
por: Lygidakis, Antonios, et al.
Publicado: (2016)

Pinpointing a Mechanistic Switch Between Ketoreduction and “Ene” Reduction in Short‐Chain Dehydrogenases/Reductases
por: Lygidakis, Antonios, et al.
Publicado: (2016)

Epimerisation of chiral hydroxylactones by short-chain dehydrogenases/reductases accounts for sex pheromone evolution in Nasonia
por: Ruther, Joachim, et al.
Publicado: (2016)

Crystal structure of a short-chain dehydrogenase/reductase from Burkholderia phymatum in complex with NAD
por: Alenazi, Jawaher, et al.
Publicado: (2022)

Imines
por: Sjögren, Gordon
Publicado: (2019)

Medium- and short-chain dehydrogenase/reductase gene and protein families: MDR and SDR gene and protein superfamilies
por: Jörnvall, H.
Publicado: (2008)

Comparative Study on Sequence–Structure–Function Relationship of the Human Short-chain Dehydrogenases/Reductases Protein Family
por: Tang, Nu Thi Ngoc, et al.
Publicado: (2014)

Structure-guided design of Serratia marcescens short-chain dehydrogenase/reductase for stereoselective synthesis of (R)-phenylephrine
por: Liu, Jai-Shin, et al.
Publicado: (2018)

A poplar short-chain dehydrogenase reductase plays a potential key role in biphenyl detoxification
por: Contreras, Ángela, et al.
Publicado: (2021)

Genome-Wide Identification and Characterization of Short-Chain Dehydrogenase/Reductase (SDR) Gene Family in Medicago truncatula
por: Yu, Shuhan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ssjlo5kk270iu00u3bhs6d6ha2