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Catalytic Enantioselective Synthesis of Heterocyclic Vicinal Fluoroamines by Using Asymmetric Protonation: Method Development and Mechanistic Study

A catalytic enantioselective synthesis of heterocyclic vicinal fluoroamines is reported. A chiral Brønsted acid promotes aza‐Michael addition to fluoroalkenyl heterocycles to give a prochiral enamine intermediate that undergoes asymmetric protonation upon rearomatization. The reaction accommodates a...

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Detalles Bibliográficos
Autores principales:	Ashford, Matthew W., Xu, Chao, Molloy, John J., Carpenter‐Warren, Cameron, Slawin, Alexandra M. Z., Leach, Andrew G., Watson, Allan J. B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540707/ https://www.ncbi.nlm.nih.gov/pubmed/32539163 http://dx.doi.org/10.1002/chem.202002543

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