Isothiourea‐Catalyzed Acylative Kinetic Resolution of Tertiary α‐Hydroxy Esters

A highly enantioselective isothiourea‐catalyzed acylative kinetic resolution (KR) of acyclic tertiary alcohols has been developed. Selectivity factors of up to 200 were achieved for the KR of tertiary alcohols bearing an adjacent ester substituent, with both reaction conversion and enantioselectivit...

Descripción completa

Detalles Bibliográficos
Autores principales: Qu, Shen, Smith, Samuel M., Laina‐Martín, Víctor, Neyyappadath, Rifahath M., Greenhalgh, Mark D., Smith, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540711/
https://www.ncbi.nlm.nih.gov/pubmed/32491267
http://dx.doi.org/10.1002/anie.202004354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540711/
https://www.ncbi.nlm.nih.gov/pubmed/32491267
http://dx.doi.org/10.1002/anie.202004354

Ejemplares similares