Structure of DNA methyltransferases DNMT3A/DNMT3B bound to a nucleosome

CpG methylation by the de novo DNA methyltransferases (DNMTs) 3A and 3B is essential for mammalian development and differentiation and is frequently dysregulated in cancer(1). These two DNMTs preferentially bind to nucleosomes yet cannot methylate the DNA wrapped around the nucleosome core(2), and f...

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Detalles Bibliográficos
Autores principales: Xu, Ting-Hai, Liu, Minmin, Zhou, X. Edward, Liang, Gangning, Zhao, Gongpu, Xu, H. Eric, Melcher, Karsten, Jones, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540737/
https://www.ncbi.nlm.nih.gov/pubmed/32968275
http://dx.doi.org/10.1038/s41586-020-2747-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540737/
https://www.ncbi.nlm.nih.gov/pubmed/32968275
http://dx.doi.org/10.1038/s41586-020-2747-1

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