Targeting the glycan of receptor binding domain with jacalin as a novel approach to develop a treatment against COVID-19

In silico analysis revealed that a lectin, jacalin from jackfruit seeds, recognizes a glycosylated region of the receptor-binding domain (RBD) of SARS-CoV2. Jacalin binding induces conformational changes in RBD and significantly affects its interaction with human angiotensin-converting enzyme 2. The...

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Detalles Bibliográficos
Autores principales: Rajendaran, Senthilnathan, Jothi, Arunchalam, Anbazhagan, Veerappan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540766/
https://www.ncbi.nlm.nih.gov/pubmed/33047045
http://dx.doi.org/10.1098/rsos.200844
Descripción
Sumario:In silico analysis revealed that a lectin, jacalin from jackfruit seeds, recognizes a glycosylated region of the receptor-binding domain (RBD) of SARS-CoV2. Jacalin binding induces conformational changes in RBD and significantly affects its interaction with human angiotensin-converting enzyme 2. The result may open up exploration of lectin-based strategies against COVID-19.

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