Targeting the glycan of receptor binding domain with jacalin as a novel approach to develop a treatment against COVID-19

In silico analysis revealed that a lectin, jacalin from jackfruit seeds, recognizes a glycosylated region of the receptor-binding domain (RBD) of SARS-CoV2. Jacalin binding induces conformational changes in RBD and significantly affects its interaction with human angiotensin-converting enzyme 2. The...

Descripción completa

Detalles Bibliográficos
Autores principales: Rajendaran, Senthilnathan, Jothi, Arunchalam, Anbazhagan, Veerappan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540766/
https://www.ncbi.nlm.nih.gov/pubmed/33047045
http://dx.doi.org/10.1098/rsos.200844
_version_ 1783591271480164352
author Rajendaran, Senthilnathan
Jothi, Arunchalam
Anbazhagan, Veerappan
author_facet Rajendaran, Senthilnathan
Jothi, Arunchalam
Anbazhagan, Veerappan
author_sort Rajendaran, Senthilnathan
collection PubMed
description In silico analysis revealed that a lectin, jacalin from jackfruit seeds, recognizes a glycosylated region of the receptor-binding domain (RBD) of SARS-CoV2. Jacalin binding induces conformational changes in RBD and significantly affects its interaction with human angiotensin-converting enzyme 2. The result may open up exploration of lectin-based strategies against COVID-19.
format Online
Article
Text
id pubmed-7540766
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Royal Society
record_format MEDLINE/PubMed
spelling pubmed-75407662020-10-11 Targeting the glycan of receptor binding domain with jacalin as a novel approach to develop a treatment against COVID-19 Rajendaran, Senthilnathan Jothi, Arunchalam Anbazhagan, Veerappan R Soc Open Sci Chemistry In silico analysis revealed that a lectin, jacalin from jackfruit seeds, recognizes a glycosylated region of the receptor-binding domain (RBD) of SARS-CoV2. Jacalin binding induces conformational changes in RBD and significantly affects its interaction with human angiotensin-converting enzyme 2. The result may open up exploration of lectin-based strategies against COVID-19. The Royal Society 2020-09-23 /pmc/articles/PMC7540766/ /pubmed/33047045 http://dx.doi.org/10.1098/rsos.200844 Text en © 2020 The Authors. http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Chemistry
Rajendaran, Senthilnathan
Jothi, Arunchalam
Anbazhagan, Veerappan
Targeting the glycan of receptor binding domain with jacalin as a novel approach to develop a treatment against COVID-19
title Targeting the glycan of receptor binding domain with jacalin as a novel approach to develop a treatment against COVID-19
title_full Targeting the glycan of receptor binding domain with jacalin as a novel approach to develop a treatment against COVID-19
title_fullStr Targeting the glycan of receptor binding domain with jacalin as a novel approach to develop a treatment against COVID-19
title_full_unstemmed Targeting the glycan of receptor binding domain with jacalin as a novel approach to develop a treatment against COVID-19
title_short Targeting the glycan of receptor binding domain with jacalin as a novel approach to develop a treatment against COVID-19
title_sort targeting the glycan of receptor binding domain with jacalin as a novel approach to develop a treatment against covid-19
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540766/
https://www.ncbi.nlm.nih.gov/pubmed/33047045
http://dx.doi.org/10.1098/rsos.200844
work_keys_str_mv AT rajendaransenthilnathan targetingtheglycanofreceptorbindingdomainwithjacalinasanovelapproachtodevelopatreatmentagainstcovid19
AT jothiarunchalam targetingtheglycanofreceptorbindingdomainwithjacalinasanovelapproachtodevelopatreatmentagainstcovid19
AT anbazhaganveerappan targetingtheglycanofreceptorbindingdomainwithjacalinasanovelapproachtodevelopatreatmentagainstcovid19

Ejemplares similares