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Discovery of direct inhibitor of KRAS oncogenic protein by natural products: a combination of pharmacophore search, molecular docking, and molecular dynamic studies

BACKGROUND AND PURPOSE: Aberrant signaling by oncogenic RAS proteins occurs in almost all human tumors. One of the promising strategies to overcome such cancers is the inhibition of KRAS protein, a subtype of RAS family involved in cell growth, differentiation, and apoptosis, through preventing its...

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Detalles Bibliográficos
Autores principales:	Hashemi, Samaneh, Sharifi, Amirhossein, Zareei, Sara, Mohamedi, Ghazale, Biglar, Mahmood, Amanlou, Massoud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer - Medknow 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540812/ https://www.ncbi.nlm.nih.gov/pubmed/33088323 http://dx.doi.org/10.4103/1735-5362.288425

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