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Prehospital use of a modified HEART Pathway and point-of-care troponin to predict cardiovascular events

The HEART Pathway is a validated risk stratification protocol for Emergency Department patients with chest pain that has yet to be tested in the prehospital setting. This study seeks to test the performance of a prehospital modified HEART Pathway (PMHP). A prospective cohort study of adults with che...

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Detalles Bibliográficos
Autores principales: Stopyra, Jason P., Snavely, Anna C., Smith, Lane M., Harris, R. David, Nelson, Robert D., Winslow, James E., Alson, Roy L., Pomper, Gregory J., Riley, Robert F., Ashburn, Nicklaus P., Hendley, Nella W., Gaddy, Jeremiah, Woodrum, Tyler, Fornage, Louis, Conner, David, Alvarez, Manrique, Pflum, Adam, Koehler, Lauren E., Miller, Chadwick D., Mahler, Simon A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540888/
https://www.ncbi.nlm.nih.gov/pubmed/33027260
http://dx.doi.org/10.1371/journal.pone.0239460
Descripción
Sumario:The HEART Pathway is a validated risk stratification protocol for Emergency Department patients with chest pain that has yet to be tested in the prehospital setting. This study seeks to test the performance of a prehospital modified HEART Pathway (PMHP). A prospective cohort study of adults with chest pain without ST-segment elevation myocardial infarction was conducted at three EMS agencies between 12/2016-1/2018. To complete a PMHP assessment, paramedics drew blood, measured point-of-care (POC) troponin (i-STAT; Abbott Point of Care) and calculated a HEAR score. Patients were stratified into three groups: high-risk based on an elevated troponin, low-risk based on a HEAR score <4 with a negative troponin, or moderate risk for a HEAR score ≥4 with a negative troponin. Sensitivity, specificity, negative and positive predictive values of the PMHP for detection of major adverse cardiac events (MACE: cardiac death, MI, or coronary revascularization) at 30-days were calculated. A total of 506 patients were accrued, with PMHP completed in 78.1% (395/506). MACE at 30-days occurred in 18.7% (74/395). Among these patients, 7.1% (28/395) were high risk yielding a specificity and PPV for 30-day MACE of 96.6% (95%CI: 94.0–98.3%) and 60.7% (95%CI: 40.6–78.6%) respectively. Low-risk assessments occurred in 31.4% (124/395), which were 90.5% (95%CI: 81.5–96.1%) sensitive for 30-day MACE with a NPV of 94.4% (95%CI: 88.7–97.7%). Moderate-risk assessments occurred in 61.5% (243/395), of which 20.6% had 30-day MACE. The PMHP is able to identify high-risk and low-risk groups with high specificity and negative predictive value for 30-day MACE. CLINICAL TRIAL REGISTRATION: clinicaltrials.gov (NCT02709135).