Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice

Cervical cancer (CC) is usually initiated by infection with high‐risk types of human papillomavirus (HPV). The HPV E6 and E7 proteins target p53 and RB, respectively, but other cellular targets likely exist. We generated uterus‐specific MOB1A/B double KO (uMob1DKO) mice, which immediately developed...

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Detalles Bibliográficos
Autores principales: Nishio, Miki, To, Yoko, Maehama, Tomohiko, Aono, Yukari, Otani, Junji, Hikasa, Hiroki, Kitagawa, Akihiro, Mimori, Koshi, Sasaki, Takehiko, Nishina, Hiroshi, Toyokuni, Shinya, Lydon, John P., Nakao, Kazuwa, Wah Mak, Tak, Kiyono, Tohru, Katabuchi, Hidetaka, Tashiro, Hironori, Suzuki, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Carcinogenesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541006/
https://www.ncbi.nlm.nih.gov/pubmed/32716083
http://dx.doi.org/10.1111/cas.14581

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