Oncogenic mutation in RAS‐RAF axis leads to increased expression of GREB1, resulting in tumor proliferation in colorectal cancer

BRAF(V600E) mutation accounts for up to 90% of all BRAF mutations in human colorectal cancer (CRC), and constitutively activates the MEK‐MAPK pathway. It is recognized that neutralizing mAbs for epidermal growth factor receptor alone are not effective for CRC with BRAF(V600E) mutation. Therefore, th...

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Detalles Bibliográficos
Autores principales: Kochi, Masatoshi, Hinoi, Takao, Niitsu, Hiroaki, Miguchi, Masashi, Saito, Yasufumi, Sada, Haruki, Sentani, Kazuhiro, Sakamoto, Naoya, Oue, Naohide, Tashiro, Hirotaka, Sotomaru, Yusuke, Yasui, Wataru, Ohdan, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Carcinogenesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541019/
https://www.ncbi.nlm.nih.gov/pubmed/32629543
http://dx.doi.org/10.1111/cas.14558

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