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Relapse‐related molecular signature in early‐stage lung adenocarcinomas based on base excision repair, stimulator of interferon genes pathway and tumor‐infiltrating lymphocytes

Approximately 30% of patients with early‐stage non–small cell lung cancer (NSCLC) relapse within 5 years after surgery. Therefore, it is necessary to identify a robust and reliable prognostic signature for early‐stage NSCLC. Immunohistochemistry data from 147 patients with stage I lung adenocarcinom...

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Autores principales: Yang, Bo, Rao, Wen, Luo, Hao, Zhang, Liang, Wang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541020/
https://www.ncbi.nlm.nih.gov/pubmed/32654272
http://dx.doi.org/10.1111/cas.14570
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author Yang, Bo
Rao, Wen
Luo, Hao
Zhang, Liang
Wang, Dong
author_facet Yang, Bo
Rao, Wen
Luo, Hao
Zhang, Liang
Wang, Dong
author_sort Yang, Bo
collection PubMed
description Approximately 30% of patients with early‐stage non–small cell lung cancer (NSCLC) relapse within 5 years after surgery. Therefore, it is necessary to identify a robust and reliable prognostic signature for early‐stage NSCLC. Immunohistochemistry data from 147 patients with stage I lung adenocarcinoma (stage I‐LUAD) were analyzed for the protein expression of base excision repair (BER), stimulator of interferon genes (STING) and tumor‐infiltrating lymphocytes (TIL) to explore the relationship between protein expression and prognosis. A prediction model was further established by nomogram and externally verified using The Cancer Genome Atlas and Gene Expression Omnibus (GEO) databases. XRCC1 and H2AX are negative prognostic markers for relapse‐free survival (RFS), while CD8, CD20 and STING are positive prognostic markers for RFS. Nomograms for RFS share common prognostic markers, including XRCC1, H2AX, STING, CD8 and CD20. The c‐index was 0.724 and 0.698 in the training cohort and the internal validation cohort, respectively. It was externally verified that the nomogram model had a good prediction for recurrence of stage I‐LUAD. Correlation analysis showed that APE1 and H2AX were negatively correlated with STING, while STING was positively correlated with TIL. BER, the STING pathway and TIL were associated with early recurrence and were correlated with the tissue expression of stage I‐LUAD. Our nomogram model was a good predictor for recurrence of stage I‐LUAD.
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spelling pubmed-75410202020-10-09 Relapse‐related molecular signature in early‐stage lung adenocarcinomas based on base excision repair, stimulator of interferon genes pathway and tumor‐infiltrating lymphocytes Yang, Bo Rao, Wen Luo, Hao Zhang, Liang Wang, Dong Cancer Sci Basic and Clinical Immunology Approximately 30% of patients with early‐stage non–small cell lung cancer (NSCLC) relapse within 5 years after surgery. Therefore, it is necessary to identify a robust and reliable prognostic signature for early‐stage NSCLC. Immunohistochemistry data from 147 patients with stage I lung adenocarcinoma (stage I‐LUAD) were analyzed for the protein expression of base excision repair (BER), stimulator of interferon genes (STING) and tumor‐infiltrating lymphocytes (TIL) to explore the relationship between protein expression and prognosis. A prediction model was further established by nomogram and externally verified using The Cancer Genome Atlas and Gene Expression Omnibus (GEO) databases. XRCC1 and H2AX are negative prognostic markers for relapse‐free survival (RFS), while CD8, CD20 and STING are positive prognostic markers for RFS. Nomograms for RFS share common prognostic markers, including XRCC1, H2AX, STING, CD8 and CD20. The c‐index was 0.724 and 0.698 in the training cohort and the internal validation cohort, respectively. It was externally verified that the nomogram model had a good prediction for recurrence of stage I‐LUAD. Correlation analysis showed that APE1 and H2AX were negatively correlated with STING, while STING was positively correlated with TIL. BER, the STING pathway and TIL were associated with early recurrence and were correlated with the tissue expression of stage I‐LUAD. Our nomogram model was a good predictor for recurrence of stage I‐LUAD. John Wiley and Sons Inc. 2020-08-04 2020-10 /pmc/articles/PMC7541020/ /pubmed/32654272 http://dx.doi.org/10.1111/cas.14570 Text en © 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Basic and Clinical Immunology
Yang, Bo
Rao, Wen
Luo, Hao
Zhang, Liang
Wang, Dong
Relapse‐related molecular signature in early‐stage lung adenocarcinomas based on base excision repair, stimulator of interferon genes pathway and tumor‐infiltrating lymphocytes
title Relapse‐related molecular signature in early‐stage lung adenocarcinomas based on base excision repair, stimulator of interferon genes pathway and tumor‐infiltrating lymphocytes
title_full Relapse‐related molecular signature in early‐stage lung adenocarcinomas based on base excision repair, stimulator of interferon genes pathway and tumor‐infiltrating lymphocytes
title_fullStr Relapse‐related molecular signature in early‐stage lung adenocarcinomas based on base excision repair, stimulator of interferon genes pathway and tumor‐infiltrating lymphocytes
title_full_unstemmed Relapse‐related molecular signature in early‐stage lung adenocarcinomas based on base excision repair, stimulator of interferon genes pathway and tumor‐infiltrating lymphocytes
title_short Relapse‐related molecular signature in early‐stage lung adenocarcinomas based on base excision repair, stimulator of interferon genes pathway and tumor‐infiltrating lymphocytes
title_sort relapse‐related molecular signature in early‐stage lung adenocarcinomas based on base excision repair, stimulator of interferon genes pathway and tumor‐infiltrating lymphocytes
topic Basic and Clinical Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541020/
https://www.ncbi.nlm.nih.gov/pubmed/32654272
http://dx.doi.org/10.1111/cas.14570
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