Lack of airway submucosal glands impairs respiratory host defenses

Submucosal glands (SMGs) are a prominent structure that lines human cartilaginous airways. Although it has been assumed that SMGs contribute to respiratory defense, that hypothesis has gone without a direct test. Therefore, we studied pigs, which have lungs like humans, and disrupted the gene for ec...

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Detalles Bibliográficos
Autores principales: Ostedgaard, Lynda S, Price, Margaret P, Whitworth, Kristin M, Abou Alaiwa, Mahmoud H, Fischer, Anthony J, Warrier, Akshaya, Samuel, Melissa, Spate, Lee D, Allen, Patrick D, Hilkin, Brieanna M, Romano Ibarra, Guillermo S, Ortiz Bezara, Miguel E, Goodell, Brian J, Mather, Steven E, Powers, Linda S, Stroik, Mallory R, Gansemer, Nicholas D, Hippee, Camilla E, Zarei, Keyan, Goeken, J Adam, Businga, Thomas R, Hoffman, Eric A, Meyerholz, David K, Prather, Randall S, Stoltz, David A, Welsh, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541087/
https://www.ncbi.nlm.nih.gov/pubmed/33026343
http://dx.doi.org/10.7554/eLife.59653

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