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Is Lugol necessary for endoscopic resection of esophageal squamous cell neoplasia?

Background and study aims  Recent evidence suggests that lugol chromoendoscopy (LCE) and narrow-band imaging (NBI) have comparable sensitivity for detection of superficial esophageal squamous cell carcinoma (SCC). However, LCE is time-consuming and associated with side effects. The aim of this study...

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Autores principales: Costa-Santos, Maria Pia, Ferreira, Alexandre Oliveira, Mouradides, Christina, Pérez-Cuadrado-Robles, Enrique, Yeung, Ralph, Garcés-Duran, Rodrigo, Snauwaert, Christophe, Dano, Hélène, Piessevaux, Hubert, Deprez, Pierre H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541178/
https://www.ncbi.nlm.nih.gov/pubmed/33043116
http://dx.doi.org/10.1055/a-1198-4316
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author Costa-Santos, Maria Pia
Ferreira, Alexandre Oliveira
Mouradides, Christina
Pérez-Cuadrado-Robles, Enrique
Yeung, Ralph
Garcés-Duran, Rodrigo
Snauwaert, Christophe
Dano, Hélène
Piessevaux, Hubert
Deprez, Pierre H.
author_facet Costa-Santos, Maria Pia
Ferreira, Alexandre Oliveira
Mouradides, Christina
Pérez-Cuadrado-Robles, Enrique
Yeung, Ralph
Garcés-Duran, Rodrigo
Snauwaert, Christophe
Dano, Hélène
Piessevaux, Hubert
Deprez, Pierre H.
author_sort Costa-Santos, Maria Pia
collection PubMed
description Background and study aims  Recent evidence suggests that lugol chromoendoscopy (LCE) and narrow-band imaging (NBI) have comparable sensitivity for detection of superficial esophageal squamous cell carcinoma (SCC). However, LCE is time-consuming and associated with side effects. The aim of this study was to compare the effectiveness of NBI and LCE in defining resection margins of esophageal SCC. Patients and methods  This was a retrospective observational cohort study of patients with esophageal SCC and dysplasia who underwent en-bloc resection between 1999 and 2017 at the Cliniques universitaires Saint-Luc, Brussels. Two groups were defined: 1) inspection with NBI only; and 2) inspection with LCE (with or without NBI). The primary endpoint was complete lateral resection rate. Multivariate regression was used to adjust for potential confounders. Results  A total of 102 patients with 132 lesions were included. Lesions were inspected with LCE in 52 % (n = 68) and with NBI only in 48 % (n = 64). Lesions 0-IIa were more frequent in the NBI group (37 %) and 0-IIb (60 %) in LCE. Lesion location, size, and histology and resection technique (endoscopic submucosal dissection in 122/132 cases, 92 %) were similar between the groups. The rate of complete lateral resection for invasive carcinoma was 90 % in LCE group and 94 % in NBI group ( P  = 0.498) and 65 % and 67 % ( P  = 0.813), respectively, for dysplasia complete lateral resection. These results remained non-significant after adjusting for potential confounders. Conclusions  Mucosal inspection and delineation of tumors with lugol chromoendoscopy before endoscopic resection of esophageal squamous cell lesions was not associated with increased complete lateral resection rate when compared to NBI.
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spelling pubmed-75411782020-10-09 Is Lugol necessary for endoscopic resection of esophageal squamous cell neoplasia? Costa-Santos, Maria Pia Ferreira, Alexandre Oliveira Mouradides, Christina Pérez-Cuadrado-Robles, Enrique Yeung, Ralph Garcés-Duran, Rodrigo Snauwaert, Christophe Dano, Hélène Piessevaux, Hubert Deprez, Pierre H. Endosc Int Open Background and study aims  Recent evidence suggests that lugol chromoendoscopy (LCE) and narrow-band imaging (NBI) have comparable sensitivity for detection of superficial esophageal squamous cell carcinoma (SCC). However, LCE is time-consuming and associated with side effects. The aim of this study was to compare the effectiveness of NBI and LCE in defining resection margins of esophageal SCC. Patients and methods  This was a retrospective observational cohort study of patients with esophageal SCC and dysplasia who underwent en-bloc resection between 1999 and 2017 at the Cliniques universitaires Saint-Luc, Brussels. Two groups were defined: 1) inspection with NBI only; and 2) inspection with LCE (with or without NBI). The primary endpoint was complete lateral resection rate. Multivariate regression was used to adjust for potential confounders. Results  A total of 102 patients with 132 lesions were included. Lesions were inspected with LCE in 52 % (n = 68) and with NBI only in 48 % (n = 64). Lesions 0-IIa were more frequent in the NBI group (37 %) and 0-IIb (60 %) in LCE. Lesion location, size, and histology and resection technique (endoscopic submucosal dissection in 122/132 cases, 92 %) were similar between the groups. The rate of complete lateral resection for invasive carcinoma was 90 % in LCE group and 94 % in NBI group ( P  = 0.498) and 65 % and 67 % ( P  = 0.813), respectively, for dysplasia complete lateral resection. These results remained non-significant after adjusting for potential confounders. Conclusions  Mucosal inspection and delineation of tumors with lugol chromoendoscopy before endoscopic resection of esophageal squamous cell lesions was not associated with increased complete lateral resection rate when compared to NBI. Georg Thieme Verlag KG 2020-10 2020-10-07 /pmc/articles/PMC7541178/ /pubmed/33043116 http://dx.doi.org/10.1055/a-1198-4316 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/) https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Costa-Santos, Maria Pia
Ferreira, Alexandre Oliveira
Mouradides, Christina
Pérez-Cuadrado-Robles, Enrique
Yeung, Ralph
Garcés-Duran, Rodrigo
Snauwaert, Christophe
Dano, Hélène
Piessevaux, Hubert
Deprez, Pierre H.
Is Lugol necessary for endoscopic resection of esophageal squamous cell neoplasia?
title Is Lugol necessary for endoscopic resection of esophageal squamous cell neoplasia?
title_full Is Lugol necessary for endoscopic resection of esophageal squamous cell neoplasia?
title_fullStr Is Lugol necessary for endoscopic resection of esophageal squamous cell neoplasia?
title_full_unstemmed Is Lugol necessary for endoscopic resection of esophageal squamous cell neoplasia?
title_short Is Lugol necessary for endoscopic resection of esophageal squamous cell neoplasia?
title_sort is lugol necessary for endoscopic resection of esophageal squamous cell neoplasia?
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541178/
https://www.ncbi.nlm.nih.gov/pubmed/33043116
http://dx.doi.org/10.1055/a-1198-4316
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