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Usefulness of (18)F-FDOPA PET for the management of primary brain tumors: a systematic review of the literature

Contrast-enhanced magnetic resonance imaging is currently the standard of care in the management of primary brain tumors, although certain limitations remain. Metabolic imaging has proven useful for an increasing number of indications in oncology over the past few years, most particularly (18)F-FDG...

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Autores principales: Somme, François, Bender, Laura, Namer, Izzie Jacques, Noël, Georges, Bund, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541204/
https://www.ncbi.nlm.nih.gov/pubmed/33023662
http://dx.doi.org/10.1186/s40644-020-00348-5
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author Somme, François
Bender, Laura
Namer, Izzie Jacques
Noël, Georges
Bund, Caroline
author_facet Somme, François
Bender, Laura
Namer, Izzie Jacques
Noël, Georges
Bund, Caroline
author_sort Somme, François
collection PubMed
description Contrast-enhanced magnetic resonance imaging is currently the standard of care in the management of primary brain tumors, although certain limitations remain. Metabolic imaging has proven useful for an increasing number of indications in oncology over the past few years, most particularly (18)F-FDG PET/CT. In neuro-oncology, (18)F-FDG was insufficient to clearly evaluate brain tumors. Amino-acid radiotracers such as (18)F-FDOPA were then evaluated in the management of brain diseases, notably tumoral diseases. Even though European guidelines on the use of amino-acid PET in gliomas have been published, it is crucial that future studies standardize acquisition and interpretation parameters. The aim of this article was to systematically review the potential effect of this metabolic imaging technique in numerous steps of the disease: primary and recurrence diagnosis, grading, local and systemic treatment assessment, and prognosis. A total of 41 articles were included and analyzed in this review. It appears that (18)F-FDOPA PET holds promise as an effective additional tool in the management of gliomas. More consistent prospective studies are still needed.
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spelling pubmed-75412042020-10-08 Usefulness of (18)F-FDOPA PET for the management of primary brain tumors: a systematic review of the literature Somme, François Bender, Laura Namer, Izzie Jacques Noël, Georges Bund, Caroline Cancer Imaging Review Contrast-enhanced magnetic resonance imaging is currently the standard of care in the management of primary brain tumors, although certain limitations remain. Metabolic imaging has proven useful for an increasing number of indications in oncology over the past few years, most particularly (18)F-FDG PET/CT. In neuro-oncology, (18)F-FDG was insufficient to clearly evaluate brain tumors. Amino-acid radiotracers such as (18)F-FDOPA were then evaluated in the management of brain diseases, notably tumoral diseases. Even though European guidelines on the use of amino-acid PET in gliomas have been published, it is crucial that future studies standardize acquisition and interpretation parameters. The aim of this article was to systematically review the potential effect of this metabolic imaging technique in numerous steps of the disease: primary and recurrence diagnosis, grading, local and systemic treatment assessment, and prognosis. A total of 41 articles were included and analyzed in this review. It appears that (18)F-FDOPA PET holds promise as an effective additional tool in the management of gliomas. More consistent prospective studies are still needed. BioMed Central 2020-10-06 /pmc/articles/PMC7541204/ /pubmed/33023662 http://dx.doi.org/10.1186/s40644-020-00348-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Somme, François
Bender, Laura
Namer, Izzie Jacques
Noël, Georges
Bund, Caroline
Usefulness of (18)F-FDOPA PET for the management of primary brain tumors: a systematic review of the literature
title Usefulness of (18)F-FDOPA PET for the management of primary brain tumors: a systematic review of the literature
title_full Usefulness of (18)F-FDOPA PET for the management of primary brain tumors: a systematic review of the literature
title_fullStr Usefulness of (18)F-FDOPA PET for the management of primary brain tumors: a systematic review of the literature
title_full_unstemmed Usefulness of (18)F-FDOPA PET for the management of primary brain tumors: a systematic review of the literature
title_short Usefulness of (18)F-FDOPA PET for the management of primary brain tumors: a systematic review of the literature
title_sort usefulness of (18)f-fdopa pet for the management of primary brain tumors: a systematic review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541204/
https://www.ncbi.nlm.nih.gov/pubmed/33023662
http://dx.doi.org/10.1186/s40644-020-00348-5
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