Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations

Heterozygous, loss-of-function mutations in the granulin gene (GRN) encoding progranulin (PGRN) are a common cause of frontotemporal dementia (FTD). Homozygous GRN mutations cause neuronal ceroid lipofuscinosis-11 (CLN11), a lysosome storage disease. PGRN is a secreted glycoprotein that can be prote...

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Detalles Bibliográficos
Autores principales: Huang, Meixiang, Modeste, Erica, Dammer, Eric, Merino, Paola, Taylor, Georgia, Duong, Duc M., Deng, Qiudong, Holler, Christopher J., Gearing, Marla, Dickson, Dennis, Seyfried, Nicholas T., Kukar, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541308/
https://www.ncbi.nlm.nih.gov/pubmed/33028409
http://dx.doi.org/10.1186/s40478-020-01037-x

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