Pre-existing antibody-mediated adverse effects prevent the clinical development of a bacterial anti-inflammatory protein

Bacterial pathogens have evolved to secrete strong anti-inflammatory proteins that target the immune system. It was long speculated whether these virulence factors could serve as therapeutics in diseases in which abnormal immune activation plays a role. We adopted the secreted chemotaxis inhibitory...

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Detalles Bibliográficos
Autores principales: Tromp, Angelino T., Zhao, Yuxi, Jongerius, Ilse, Heezius, Erik C. J. M., Abrial, Pauline, Ruyken, Maartje, van Strijp, Jos A. G., de Haas, Carla J. C., Spaan, András N., van Kessel, Kok P. M., Henry, Thomas, Haas, Pieter-Jan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541340/
https://www.ncbi.nlm.nih.gov/pubmed/32471891
http://dx.doi.org/10.1242/dmm.045534

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